{"id":"W4417345728","doi":"10.64898/2025.12.11.25337743","title":"Helping Underdeveloped Lungs with Cells (HULC)-2 Mesenchymal Stromal Cells in extreme preterm infants at risk of developing Bronchopulmonary Dysplasia – A Phase 2 Multi-Centre Double Blind Randomized Controlled Trial Study Protocol","year":2025,"lang":"","type":"article","venue":"medRxiv","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Ottawa Hospital","funders":"Canadian Institutes of Health Research; Stem Cell Network","keywords":"Bronchopulmonary dysplasia; Randomized controlled trial; Mesenchymal stem cell; Umbilical cord; Gestational age; Mechanical ventilation; Clinical trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006710198,0.003749572,0.006251349,0.0007373699,0.001168977,0.002070353,0.001811562,0.003764789,0.0191949],"category_scores_gemma":[0.006395876,0.001207139,0.002569105,0.0008220315,0.001667439,0.001247557,0.0007623382,0.002920796,0.002922762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001404196,"about_ca_system_score_gemma":0.005203843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001042264,"about_ca_topic_score_gemma":0.002187339,"domain_scores_codex":[0.9970272,0.001537119,0.0002635705,0.000452894,0.0003033961,0.000415701],"domain_scores_gemma":[0.9974476,0.0006170238,0.0006798372,0.0002019728,0.0004438267,0.0006097294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9751805,0.007243076,0.0003594922,0.004830539,0.001086205,0.00004365828,0.00005422481,0.0003536935,0.001580415,0.0003098472,0.001654255,0.007303976],"study_design_scores_gemma":[0.9643179,0.03133298,0.0006681453,0.000282257,0.0006030619,0.00001459345,0.0000189614,0.0003592609,0.0003519107,0.0002314017,0.001800581,0.00001902229],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1239948,0.005596641,0.004171873,0.001144424,0.001760797,0.8538254,0.005082898,0.0002880251,0.004135143],"genre_scores_gemma":[0.09532949,0.001622106,0.005075743,0.0008953644,0.0003388236,0.89306,0.0008408264,0.00001834401,0.002819232],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0191949,"threshold_uncertainty_score":0.06421334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08334770081893877,"score_gpt":0.3978687358246989,"score_spread":0.3145210350057601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}