{"id":"W4417350360","doi":"10.1111/jgs.70247","title":"Persistent Functional Impairment as an Early Indicator of Alzheimer Disease Pathology and Progression","year":2025,"lang":"en","type":"article","venue":"Journal of the American Geriatrics Society","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Dementia; Alzheimer's disease; Disease; Functional impairment; Psychological intervention; Operationalization; MEDLINE; Biomarker","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001537051,0.0004864397,0.0003287328,0.001186871,0.0003356297,0.0008044089,0.0003934949,0.0003874678,0.00132534],"category_scores_gemma":[0.002716096,0.0001105073,0.0003934317,0.0008869235,0.0003660652,0.000492294,0.0005992391,0.0006511047,0.0001835608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000314224,"about_ca_system_score_gemma":0.0003720373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004431551,"about_ca_topic_score_gemma":0.006365464,"domain_scores_codex":[0.9996384,0.00008431368,0.00005204,0.00009563682,0.00007420623,0.00005533124],"domain_scores_gemma":[0.9972982,0.0004528545,0.001534484,0.0001132214,0.0002841709,0.0003171081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001998405,0.00002888651,0.9959241,0.00002852494,0.00006616415,0.00005190531,0.00004982814,0.00007322383,0.0001187481,0.00002354296,0.0001007971,0.003334315],"study_design_scores_gemma":[0.000003445921,0.00009024929,0.9992394,0.00001387511,0.00003116134,0.0001605269,0.00004560536,0.0001711701,0.00004710062,0.00007000653,0.0001246499,0.000002852864],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960395,0.001825463,0.0002925759,0.00007318491,0.0000137958,0.00001507647,0.0009371677,0.00001552341,0.0007876848],"genre_scores_gemma":[0.9988292,0.0002784667,0.0002255094,0.00001543218,0.00001482144,0.00001011665,0.0004790375,0.00000139678,0.0001460636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004431551,"threshold_uncertainty_score":0.008811474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314718462099517,"score_gpt":0.3218622724062991,"score_spread":0.3087150877853039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}