{"id":"W4417359809","doi":"10.3390/ijms262412082","title":"The Role of Natural Chalcones and Their Derivatives in Targeting Prostate Cancer: Recent Updates","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Hops Chemistry and Applications","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Prostate cancer; Metastasis; Prostate; Cancer; Chalcone; Androgen receptor; Cell cycle checkpoint","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000647759,0.0006710089,0.0009329546,0.001693993,0.0002456956,0.001090753,0.0005418143,0.0008242987,0.003211304],"category_scores_gemma":[0.0006438399,0.0002718447,0.0004940566,0.001508768,0.0003816432,0.00127092,0.0005231777,0.001555637,0.00111335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004734753,"about_ca_system_score_gemma":0.0007747182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007512047,"about_ca_topic_score_gemma":0.001432312,"domain_scores_codex":[0.9998261,0.00003456351,0.00002582232,0.00003322444,0.0000601789,0.00002001182],"domain_scores_gemma":[0.9996091,0.0001638879,0.00005059321,0.00001188934,0.000128115,0.00003647513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002835508,0.0002005494,0.0006101903,0.01706596,0.0001461598,0.0003837744,0.0001287737,0.0007866493,0.01067182,0.004400201,0.02488354,0.9404389],"study_design_scores_gemma":[0.00004296295,0.0006366628,0.001767733,0.001375154,0.000314499,0.00155428,0.0001169226,0.0003605552,0.003947279,0.002163321,0.9876766,0.00004405635],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009058855,0.9960967,0.000432078,0.0005093252,0.0004346275,0.00001236389,0.00004181093,0.00001856606,0.001548707],"genre_scores_gemma":[0.003393182,0.9938752,0.0004723241,0.0004727065,0.0006809135,0.0000152066,0.00008486879,0.000003591835,0.001002092],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003211304,"threshold_uncertainty_score":0.01074284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02705492353085741,"score_gpt":0.4152963114391607,"score_spread":0.3882413879083033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}