{"id":"W4417359837","doi":"10.1038/s41587-025-02884-6","title":"Antibody-lectin chimeras for glyco-immune checkpoint blockade","year":2025,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Blockade; Immune checkpoint; Immune system; Antibody; Immunotherapy; Glycan; Cell cycle checkpoint; Cancer immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001747272,0.0003151201,0.0001696909,0.0002087933,0.0000936871,0.0002997363,0.0003243341,0.0003967053,0.001286333],"category_scores_gemma":[0.0001120316,0.0001273858,0.0003104939,0.0001482435,0.0001603313,0.0002186868,0.0002679374,0.0008628129,0.0002739624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005023319,"about_ca_system_score_gemma":0.0002509211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004689984,"about_ca_topic_score_gemma":0.0005989425,"domain_scores_codex":[0.9998678,0.00002719121,0.000007633883,0.00002893763,0.00003515949,0.00003328954],"domain_scores_gemma":[0.9999484,0.000008632543,0.00001452097,0.0000073111,0.000004358461,0.00001677022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000181273,0.0001009592,0.00009071569,0.00004185642,0.00001984806,0.0000386539,0.000008317052,0.0005374137,0.9939018,0.0007670976,0.0001971286,0.004114757],"study_design_scores_gemma":[0.00009032399,0.0008174627,0.0007399923,0.000009564013,0.00003859002,0.0003757497,0.000006318534,0.002123263,0.9814364,0.0001706265,0.0141825,0.00000914462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9383548,0.005424696,0.04680163,0.0004374876,0.0002495504,0.000364244,0.0007928676,0.0006334187,0.006941323],"genre_scores_gemma":[0.983986,0.001546749,0.01080986,0.0001877425,0.00001456978,0.0001109825,0.0004914511,0.00004662875,0.002806081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286333,"threshold_uncertainty_score":0.004303217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009466024272465637,"score_gpt":0.357532571165515,"score_spread":0.3480665468930494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}