{"id":"W4417361587","doi":"10.1002/jev2.70189","title":"Calibration of Flow Cytometers Enables Reproducible Measurements of Extracellular Vesicle Concentrations and Reference Range Establishment","year":2025,"lang":"en","type":"article","venue":"Journal of Extracellular Vesicles","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Oil Sands Technology and Research Authority","funders":"European Metrology Programme for Innovation and Research; National Cancer Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Commission","keywords":"Calibration; Extracellular vesicles; Reference values; Range (aeronautics); Extracellular vesicle; Calibration curve; Biomarker; Blood flow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00151739,0.0002485819,0.0004557954,0.0002393186,0.00009362922,0.00005090183,0.0003874154,0.0001803139,0.00003083647],"category_scores_gemma":[0.0005757931,0.0002419407,0.0001955587,0.0003223112,0.0002988789,0.0000710551,0.000113822,0.0001781809,6.143317e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004458317,"about_ca_system_score_gemma":0.0003377156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000151168,"about_ca_topic_score_gemma":0.000008083246,"domain_scores_codex":[0.9972374,0.0002738737,0.001286338,0.0004212506,0.0005007514,0.0002803973],"domain_scores_gemma":[0.9975548,0.00006579464,0.001000065,0.0006519048,0.0005711051,0.0001563615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003791188,0.0004305253,0.0159684,0.0002299631,0.000229106,0.00001570421,0.0001409169,0.0008854616,0.977458,0.0003870003,0.0008276796,0.003048097],"study_design_scores_gemma":[0.001427444,0.000377445,0.002586952,0.0002363845,0.0002224334,0.00002226974,0.0003180242,0.000561293,0.9916797,0.0003840005,0.001986381,0.0001976898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9307166,0.0478448,0.02035435,0.0001882988,0.0002028372,0.0003252687,0.00003290309,0.000007512612,0.0003274053],"genre_scores_gemma":[0.9848701,0.0007975352,0.01364135,0.00003055071,0.00009334995,0.000007082032,0.00003258012,0.0000255753,0.0005018841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05415347,"threshold_uncertainty_score":0.9866055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02704219319093713,"score_gpt":0.2703853882104649,"score_spread":0.2433431950195278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}