{"id":"W4417362578","doi":"10.1016/j.nbd.2025.107223","title":"MAPK family members differentially regulate pThr175 tau-mediated pathogenicity","year":2025,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Phosphorylation; Kinase; Phosphorylation cascade; p38 mitogen-activated protein kinases; Amyotrophic lateral sclerosis; MAPK/ERK pathway; Chronic traumatic encephalopathy; Tau protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599098,0.0005796376,0.0002290407,0.0003482188,0.0002370783,0.0002829328,0.0001907806,0.000269537,0.001676768],"category_scores_gemma":[0.0001842849,0.0001519827,0.0003895032,0.0001180832,0.0002340881,0.0002657018,0.0002820411,0.0004578251,0.0004756684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002232486,"about_ca_system_score_gemma":0.0001137715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001937312,"about_ca_topic_score_gemma":0.0001990221,"domain_scores_codex":[0.9998555,0.00002086569,0.000009025754,0.00002541945,0.00003340053,0.00005579562],"domain_scores_gemma":[0.9998488,0.00001092547,0.00006157739,0.000008044263,0.00002569864,0.00004477685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002939705,0.00003276312,0.0008353234,0.0000662478,0.000007558737,0.0003401239,0.0000709864,0.00004811148,0.9966633,0.0001065873,0.00009037643,0.001444608],"study_design_scores_gemma":[0.0000919146,0.0008243482,0.1162747,0.0000318471,0.00007892989,0.00324586,0.0004358298,0.002579309,0.8687989,0.0006861585,0.006920151,0.00003209718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946718,0.001745546,0.001574842,0.000120198,0.00003289866,0.00004067493,0.000181351,0.00008990215,0.001542868],"genre_scores_gemma":[0.9962,0.001022752,0.0008161008,0.00004608576,0.000023541,0.00005132518,0.0002713722,0.00001275177,0.001556068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676768,"threshold_uncertainty_score":0.005609334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01653463317025356,"score_gpt":0.2885331729384499,"score_spread":0.2719985397681964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}