{"id":"W4417366057","doi":"10.1002/advs.202513245","title":"Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University; New York University Abu Dhabi","keywords":"Follicular dendritic cells; Immune system; Acquired immune system; Stromal cell; Dendritic cell; CXCL13; Chemokine; Peripheral blood mononuclear cell; B cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000199383,0.0003756353,0.0001912562,0.0002094018,0.0001057009,0.0004838583,0.0002337952,0.000352797,0.001129212],"category_scores_gemma":[0.00006496494,0.0001577714,0.0002804422,0.0001110534,0.0001490588,0.0001258464,0.0002824978,0.0004085524,0.000415508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002059799,"about_ca_system_score_gemma":0.0002350941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004048727,"about_ca_topic_score_gemma":0.0005063827,"domain_scores_codex":[0.9998844,0.00002541432,0.000006298938,0.00002649131,0.00003601451,0.00002138328],"domain_scores_gemma":[0.9999387,0.000009722021,0.00001967851,0.000009759755,0.000006718826,0.00001545295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001476234,0.0001391928,0.0004055674,0.00007821081,0.00001139453,0.0002225262,0.00002954736,0.002158429,0.9921023,0.0004572306,0.0002566029,0.003991438],"study_design_scores_gemma":[0.0000888986,0.001732265,0.002811086,0.00002933038,0.00007066173,0.00137939,0.00008393393,0.02202235,0.9528829,0.000338447,0.01853663,0.00002421071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9204701,0.001677554,0.07028278,0.0002456945,0.0001732172,0.0002598934,0.0009405201,0.0006104745,0.005339764],"genre_scores_gemma":[0.9747019,0.0005688356,0.02175057,0.0001254984,0.00001851271,0.00021745,0.0004030603,0.00003728068,0.002176838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129212,"threshold_uncertainty_score":0.003777564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008516897627000341,"score_gpt":0.2061258552084097,"score_spread":0.1976089575814094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}