{"id":"W4417401012","doi":"10.1021/acs.jafc.5c14071","title":"Synthesis, Anthelmintic Activity, and Mechanism of Action of 5-Aryl-1 <i>H</i> -indoles","year":2025,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Helminth infection and control","field":"Veterinary","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Erasmus+; National Institutes of Health; Technologická Agentura České Republiky; Deutscher Akademischer Austauschdienst; NextGenerationEU; Technology Agency of the Czech Republic; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; European Commission","keywords":"Anthelmintic; Cytotoxicity; Mechanism of action; Mitochondrion; Toxicity; Nematode; Motility; Structure–activity relationship","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001389481,0.000269781,0.0001256798,0.0001908259,0.0001183687,0.0001098268,0.0002832669,0.0001685195,0.0008592313],"category_scores_gemma":[0.0001208273,0.00008811602,0.0001869976,0.000141494,0.0001034442,0.0001270779,0.00006233678,0.0001909748,0.0002295636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001877489,"about_ca_system_score_gemma":0.0001992095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007830727,"about_ca_topic_score_gemma":0.001442598,"domain_scores_codex":[0.9999483,0.00001010153,0.000006348929,0.000008527431,0.00001077062,0.00001609548],"domain_scores_gemma":[0.999939,0.000008771581,0.00001858708,0.000006228174,0.00001375372,0.00001368398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001164132,0.00005048992,0.0001553114,0.00009519279,0.000006556742,0.00009495432,0.00002249702,0.0003440049,0.9941142,0.0001175978,0.00004997661,0.004832896],"study_design_scores_gemma":[0.00002930988,0.001604486,0.003563406,0.00001278833,0.00002605816,0.0001660331,0.00002543326,0.000580855,0.9903253,0.00002985369,0.003627489,0.000009036886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842826,0.005042502,0.006183071,0.00008886908,0.00002651584,0.0001730675,0.0008640696,0.00008110288,0.003258207],"genre_scores_gemma":[0.987294,0.003018385,0.006906552,0.00004944316,0.00001396453,0.00005846767,0.0007688249,0.00001088353,0.001879414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008592313,"threshold_uncertainty_score":0.002874434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193912077182898,"score_gpt":0.2602729331907614,"score_spread":0.2408817254724716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}