{"id":"W4417401012","doi":"10.1021/acs.jafc.5c14071","title":"Synthesis, Anthelmintic Activity, and Mechanism of Action of 5-Aryl-1 <i>H</i> -indoles","year":2025,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Helminth infection and control","field":"Veterinary","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Erasmus+; National Institutes of Health; Technologická Agentura České Republiky; Deutscher Akademischer Austauschdienst; NextGenerationEU; Technology Agency of the Czech Republic; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; European Commission","keywords":"Anthelmintic; Cytotoxicity; Mechanism of action; Mitochondrion; Toxicity; Nematode; Motility; Structure–activity relationship","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094869,0.0001053306,0.0002984482,0.00003342511,0.00004151323,0.00001440353,0.00006426925,0.00009865469,0.00002483484],"category_scores_gemma":[0.00006298929,0.0000653941,0.0001036229,0.000089364,0.00004649052,0.0001215696,0.00003897241,0.0001559394,2.123078e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001685272,"about_ca_system_score_gemma":0.00002196882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006934487,"about_ca_topic_score_gemma":0.000001267325,"domain_scores_codex":[0.9993942,0.0000158483,0.0003008807,0.00008591091,0.0001190925,0.0000841143],"domain_scores_gemma":[0.9992988,0.00009407613,0.000359065,0.00005598424,0.0001399866,0.0000521186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001392483,0.00009615085,0.0002902375,0.0003704383,0.000156836,0.000002533844,0.00004771335,5.481286e-7,0.9928287,0.00009282301,0.00009635337,0.005878381],"study_design_scores_gemma":[0.0004381479,0.000286365,0.03100027,0.0002687665,0.000122388,0.0006042075,0.0005660747,0.000006806571,0.9663659,0.0002027002,0.00006565873,0.00007276549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980676,0.0003895925,0.0000732831,0.0003392686,0.00008754956,0.00004182226,0.000009260962,0.000006136888,0.0009854694],"genre_scores_gemma":[0.9995058,0.0002602137,0.00003009472,0.00001200363,0.00007171636,0.000001804989,3.51295e-7,0.000002676405,0.0001153365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03071003,"threshold_uncertainty_score":0.2666694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193912077182898,"score_gpt":0.2602729331907614,"score_spread":0.2408817254724716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}