{"id":"W4417411782","doi":"10.1111/bpa.70059","title":"14‐3‐3σ up‐regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders","year":2025,"lang":"en","type":"article","venue":"Brain Pathology","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"European Regional Development Fund; Instituto de Salud Carlos III; Ministerio de Ciencia e Innovación","keywords":"Temporal cortex; Glial fibrillary acidic protein; Astrocyte; Lewy body; Colocalization; Immunohistochemistry; Gene isoform; Cerebral cortex","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008349238,0.0002645567,0.0002517332,0.0007205901,0.000267568,0.0002499541,0.00008676359,0.0002154832,0.0007724576],"category_scores_gemma":[0.0001338805,0.0001795858,0.0001849783,0.0003340295,0.000321504,0.0001049157,0.0001662634,0.0002327691,0.0001630239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002095759,"about_ca_system_score_gemma":0.00015705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001961561,"about_ca_topic_score_gemma":0.00276782,"domain_scores_codex":[0.9999336,0.000007358719,0.000006976543,0.00001780789,0.00001990619,0.00001427121],"domain_scores_gemma":[0.9998788,0.000009946472,0.00006302199,0.00000569871,0.00001848965,0.00002408499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001109167,0.00005428922,0.09285655,0.00007271535,0.00008391328,0.001878031,0.0002219412,0.00003867551,0.8990099,0.00004878219,0.00009946842,0.004526564],"study_design_scores_gemma":[0.00001718434,0.0001528151,0.9612083,0.00001071119,0.00007585905,0.004483577,0.0001923837,0.0002330823,0.03302382,0.0001491975,0.0004456223,0.000007387102],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987689,0.0006822674,0.0001987691,0.00002078529,0.000003059737,0.000004184119,0.0000654233,0.0000115969,0.0002450158],"genre_scores_gemma":[0.9987651,0.0003498732,0.0002596557,0.00003070329,0.000005367754,0.000008062503,0.0001467976,0.000004523085,0.0004299788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001961561,"threshold_uncertainty_score":0.003900349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003761172794911417,"score_gpt":0.250776056024593,"score_spread":0.2470148832296816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}