{"id":"W4417412714","doi":"10.33540/3350","title":"Empowering CAR T Cell Therapy","year":2025,"lang":"","type":"dissertation","venue":"","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Granzyme B; Cytotoxic T cell; T cell; Chimeric antigen receptor; Granzyme; Immune system; Immunotherapy; Effector","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002233825,0.0003743291,0.0002637312,0.0002795855,0.0002195959,0.0009804817,0.0003943955,0.0008345717,0.007357765],"category_scores_gemma":[0.0001753822,0.0002434456,0.0003959368,0.0001844476,0.0003021585,0.0005956755,0.0008211327,0.001416878,0.0027326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004927348,"about_ca_system_score_gemma":0.0004445524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002634244,"about_ca_topic_score_gemma":0.0004660131,"domain_scores_codex":[0.999831,0.0000245404,0.000005432677,0.00003858299,0.00005556761,0.00004487231],"domain_scores_gemma":[0.9999557,0.00001122576,0.000007132493,0.000004780235,0.00001028733,0.00001089858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002122023,0.0003036919,0.0004687242,0.001464462,0.00005309986,0.0004478377,0.0003300386,0.006498788,0.5704042,0.06180232,0.03677817,0.3212364],"study_design_scores_gemma":[0.0000886987,0.000662847,0.0003575018,0.0001296649,0.00005077228,0.0007514652,0.00006411561,0.006801138,0.2571729,0.01052188,0.7233657,0.00003338681],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"other","genre_scores_codex":[0.1863865,0.2314063,0.3239986,0.0130717,0.004215137,0.0009909194,0.001425823,0.003926917,0.2345782],"genre_scores_gemma":[0.6213543,0.1474689,0.09114518,0.007635757,0.001374238,0.001085218,0.001118054,0.0003857508,0.1284326],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.007357765,"threshold_uncertainty_score":0.02461421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03078821477318786,"score_gpt":0.3795749101656454,"score_spread":0.3487866953924575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}