{"id":"W4417420293","doi":"10.1038/s44400-025-00049-5","title":"Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk","year":2025,"lang":"en","type":"article","venue":"npj Dementia","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; National Human Genome Research Institute; Weston Brain Institute; National Institute on Aging; Alzheimer's Association","keywords":"Enhancer; Expression quantitative trait loci; Locus (genetics); Functional genomics; CRISPR; Quantitative trait locus; Allele; Disease; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006634282,0.000330897,0.000465694,0.001535631,0.0003104515,0.0005685331,0.0003795289,0.0003939632,0.00353507],"category_scores_gemma":[0.000913515,0.0001838917,0.0007728615,0.001397386,0.0002065952,0.0001420319,0.0004309527,0.000492134,0.0003965162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002887556,"about_ca_system_score_gemma":0.000309492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003354308,"about_ca_topic_score_gemma":0.006623087,"domain_scores_codex":[0.9994351,0.000100951,0.00004757207,0.0002370745,0.0001105187,0.00006873531],"domain_scores_gemma":[0.9993592,0.0002872438,0.0001886473,0.00006553956,0.0000444157,0.00005492783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003190803,0.0002358064,0.5177761,0.0009163937,0.00289099,0.003244609,0.0003027871,0.006823921,0.373688,0.002326371,0.004896201,0.08370797],"study_design_scores_gemma":[0.0001416336,0.0003823853,0.9321014,0.000124801,0.002064118,0.002950965,0.0001658955,0.01244412,0.03497846,0.002501263,0.01207491,0.00007000289],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670503,0.001282699,0.009263967,0.0002523535,0.000034544,0.0000328317,0.02006133,0.0003197707,0.001702254],"genre_scores_gemma":[0.9847882,0.0003454744,0.007032142,0.0001530766,0.00001734303,0.0000268771,0.007003468,0.00006541904,0.0005680195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00353507,"threshold_uncertainty_score":0.01182598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008745579043411604,"score_gpt":0.2769489071626668,"score_spread":0.2682033281192552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}