{"id":"W4417420457","doi":"10.1186/s13073-025-01561-2","title":"Genetic liability to psoriasis predicts severe disease outcomes","year":2025,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Nexus Clinical Research (Canada); Memorial University of Newfoundland; University Health Network","funders":"Janssen Biotech; Faculty of Medicine and Health, University of Sydney; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Medical School, University of Michigan; National Institutes of Health; King's College London; Business Finland; Norges Forskningsråd; Genentech; King's Health Partners; National Institute for Health and Care Research; Maze Therapeutics; British Association of Dermatologists; Wellcome Trust; Sanofi; Norges Teknisk-Naturvitenskapelige Universitet; Eesti Teadusagentuur; European Federation of Pharmaceutical Industries and Associations; School of Public Health, University of Michigan; Novartis Pharma; European Commission; Norwegian Institute of Public Health; Celgene; Pfizer; Biogen; Helse Midt-Norge; GlaxoSmithKline; Bristol-Myers Squibb; AstraZeneca","keywords":"Psoriasis; Disease; Epidemiology; Human genetics; Risk stratification; Genetic predisposition; Liability; Severity of illness","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000231964,0.0002724437,0.0004883159,0.0002237821,0.0001773421,0.000005759292,0.0003029805,0.000139121,0.001640827],"category_scores_gemma":[0.0003748128,0.0001957706,0.0001105591,0.0003584331,0.0001586032,0.00002936861,0.0001235718,0.0001121196,0.0007612653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009349665,"about_ca_system_score_gemma":0.0001071919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008887574,"about_ca_topic_score_gemma":0.00002661882,"domain_scores_codex":[0.9984985,0.0001636076,0.0003684414,0.0004922254,0.00006393682,0.0004133137],"domain_scores_gemma":[0.9988782,0.0001988358,0.0000554032,0.0006713037,0.000076661,0.0001195471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001164651,0.0005377413,0.8088719,0.0002143561,0.001579978,0.00007493085,0.00163366,0.00006245587,0.02351254,0.0006772557,0.02483451,0.1368361],"study_design_scores_gemma":[0.002421612,0.0001717217,0.8804695,0.00005045954,0.0004704268,0.000004473422,0.00009756069,6.7745e-7,0.0002866684,0.0004928648,0.1153705,0.0001635326],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730165,0.01000438,0.0003447296,0.007713082,0.002885153,0.0007759478,0.0001533618,0.0001676923,0.004939152],"genre_scores_gemma":[0.970156,0.0001551329,0.0001566064,0.001873292,0.0001475278,0.0001396816,0.0001528166,0.00001540283,0.02720356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1366725,"threshold_uncertainty_score":0.9992718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267928390530141,"score_gpt":0.2514943901539594,"score_spread":0.238815106248658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}