{"id":"W4417420457","doi":"10.1186/s13073-025-01561-2","title":"Genetic liability to psoriasis predicts severe disease outcomes","year":2025,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Nexus Clinical Research (Canada); Memorial University of Newfoundland; University Health Network","funders":"Janssen Biotech; Faculty of Medicine and Health, University of Sydney; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Medical School, University of Michigan; National Institutes of Health; King's College London; Business Finland; Norges Forskningsråd; Genentech; King's Health Partners; National Institute for Health and Care Research; Maze Therapeutics; British Association of Dermatologists; Wellcome Trust; Sanofi; Norges Teknisk-Naturvitenskapelige Universitet; Eesti Teadusagentuur; European Federation of Pharmaceutical Industries and Associations; School of Public Health, University of Michigan; Novartis Pharma; European Commission; Norwegian Institute of Public Health; Celgene; Pfizer; Biogen; Helse Midt-Norge; GlaxoSmithKline; Bristol-Myers Squibb; AstraZeneca","keywords":"Psoriasis; Disease; Epidemiology; Human genetics; Risk stratification; Genetic predisposition; Liability; Severity of illness","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00226344,0.0004813115,0.0005483854,0.0009816259,0.0003466754,0.0008964451,0.000330483,0.0005784379,0.003470036],"category_scores_gemma":[0.00591927,0.0002390342,0.001566754,0.001446183,0.0004813621,0.0002842067,0.0007160307,0.0008128134,0.0002494431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036306,"about_ca_system_score_gemma":0.0003074126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001672554,"about_ca_topic_score_gemma":0.001285168,"domain_scores_codex":[0.9984174,0.0006567175,0.0001501543,0.0004499225,0.0001998098,0.0001258994],"domain_scores_gemma":[0.9925632,0.002939035,0.002862586,0.0007153491,0.0003264268,0.0005934605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007896553,0.00003789441,0.9903662,0.0001010884,0.002849992,0.0001414286,0.00004640097,0.0005768334,0.0006796214,0.0001203952,0.0002721781,0.004018366],"study_design_scores_gemma":[0.00005105411,0.0001472929,0.9953848,0.00004644715,0.001714107,0.0005349928,0.00003863817,0.0009360207,0.0001643384,0.0006145055,0.0003598492,0.000007919797],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919856,0.003975946,0.001226193,0.0004470124,0.00002984986,0.0000206774,0.00106609,0.00002569776,0.001223145],"genre_scores_gemma":[0.9987345,0.0004267668,0.0002166689,0.00004023638,0.00003375681,0.000006711874,0.0004423332,0.000004648146,0.0000943483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003470036,"threshold_uncertainty_score":0.01197034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267928390530141,"score_gpt":0.2514943901539594,"score_spread":0.238815106248658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}