{"id":"W4417424232","doi":"10.1182/blood-2025-482","title":"Preliminary data from the Phase I/II study of nuvisertib, an oral investigational selective PIM1 inhibitor, in combination with momelotinib showed clinical responses in patients with relapsed/refractory myelofibrosis","year":2025,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ruxolitinib; Myelofibrosis; PIM1; Phases of clinical research; Bone marrow; Combination therapy; Janus kinase inhibitor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00134914,0.001021813,0.001297791,0.0002146285,0.0003820247,0.0007255842,0.0004885845,0.000744821,0.003280254],"category_scores_gemma":[0.0006740495,0.0002271415,0.0009922311,0.0002515547,0.0003780012,0.0004527554,0.0002356415,0.002206899,0.0007359963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004562145,"about_ca_system_score_gemma":0.000742169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005738887,"about_ca_topic_score_gemma":0.001818934,"domain_scores_codex":[0.9997031,0.0001234991,0.00002430499,0.00004330471,0.00004379035,0.00006201853],"domain_scores_gemma":[0.9994697,0.000120419,0.00007492337,0.00005578829,0.00006317886,0.0002159678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1299726,0.0431962,0.01405496,0.002752502,0.003332459,0.00139075,0.0004581803,0.004390949,0.4847544,0.0005208213,0.02577415,0.2894021],"study_design_scores_gemma":[0.09195636,0.5869136,0.08797828,0.0003205843,0.00471255,0.004548775,0.0001724699,0.004167842,0.1703465,0.0007565492,0.04801571,0.0001107106],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.962783,0.01463491,0.002822292,0.001844549,0.0002076872,0.002077317,0.006884522,0.0004591498,0.008286585],"genre_scores_gemma":[0.9731417,0.004960551,0.002618975,0.001495692,0.0001908263,0.001054207,0.01245167,0.00007500623,0.004011314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003280254,"threshold_uncertainty_score":0.01097351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04823130709713899,"score_gpt":0.3445007417979566,"score_spread":0.2962694347008177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}