{"id":"W4417427033","doi":"10.1212/wnl.0000000000214454","title":"Lipoic Acid for Treatment of Progressive Multiple Sclerosis","year":2025,"lang":"en","type":"article","venue":"Neurology","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Multiple sclerosis; Lipoic acid; Dimethyl fumarate; Clinical trial; Disease; Clinical neurology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006565843,0.0003233366,0.0005894248,0.0003091979,0.0001254568,0.0002629769,0.0002831117,0.0004107973,0.003104497],"category_scores_gemma":[0.0004403614,0.00007613703,0.0002969475,0.0002156749,0.0002430101,0.0001496713,0.0001402326,0.0006569492,0.0003332956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997904,"about_ca_system_score_gemma":0.0004537297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005743508,"about_ca_topic_score_gemma":0.001221396,"domain_scores_codex":[0.9998797,0.00005660266,0.00001566127,0.00001628149,0.00001988728,0.00001186994],"domain_scores_gemma":[0.9998249,0.0000428101,0.00007163971,0.000007059562,0.00001572974,0.00003788701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2736106,0.009329223,0.003351208,0.009024167,0.001285793,0.0002831208,0.0001536306,0.0005799246,0.05198205,0.0004354388,0.003449101,0.6465158],"study_design_scores_gemma":[0.5977068,0.3023609,0.03690318,0.001791838,0.00295476,0.001329789,0.0001459966,0.001533889,0.01749086,0.0009644096,0.03677103,0.00004655246],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.824421,0.1672382,0.001318845,0.001479928,0.0004224661,0.001277343,0.0006222099,0.0001832025,0.003036859],"genre_scores_gemma":[0.9471546,0.04455465,0.003020523,0.001207099,0.0004113068,0.0008888511,0.0004587932,0.0000137382,0.002290439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003104497,"threshold_uncertainty_score":0.01038563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02864764555294029,"score_gpt":0.295120452595871,"score_spread":0.2664728070429307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}