{"id":"W4417427033","doi":"10.1212/wnl.0000000000214454","title":"Lipoic Acid for Treatment of Progressive Multiple Sclerosis","year":2025,"lang":"en","type":"article","venue":"Neurology","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Multiple sclerosis; Lipoic acid; Dimethyl fumarate; Clinical trial; Disease; Clinical neurology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003257977,0.0001007284,0.0001707033,0.00003668035,0.00004679316,0.000003191229,0.0001164447,0.0001349348,0.000004272265],"category_scores_gemma":[0.0002097321,0.00008023779,0.00009949372,0.00006479481,0.0001998217,7.092877e-7,0.00009783517,0.00002666631,0.0000013614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005449627,"about_ca_system_score_gemma":0.00003936488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009186313,"about_ca_topic_score_gemma":0.00001702308,"domain_scores_codex":[0.9992988,0.00003604295,0.0001271474,0.0002781953,0.00004398841,0.0002157962],"domain_scores_gemma":[0.9995637,0.00005227313,0.00004161855,0.0002140548,0.00009812161,0.0000302276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00115571,0.0001985126,0.005015086,0.00002926801,0.000114056,9.738291e-7,0.0000109133,0.000002057865,0.9840604,0.00004180634,0.001335721,0.008035515],"study_design_scores_gemma":[0.00122767,0.003953618,0.004413671,0.000003785301,0.00001880323,0.000001489802,0.000002974213,0.00003112101,0.9604041,0.00008882689,0.02980035,0.00005356399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936599,0.003570128,0.0003021547,0.001594369,0.0001114947,0.0004530571,0.00004443973,0.00000912303,0.0002553154],"genre_scores_gemma":[0.998197,0.0004386331,0.0004223693,0.0003391907,0.00008141991,0.0003165566,0.00003844218,0.000007961166,0.0001584124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02846463,"threshold_uncertainty_score":0.3272002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02864764555294029,"score_gpt":0.295120452595871,"score_spread":0.2664728070429307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}