{"id":"W4417427231","doi":"10.1136/bmjopen-2025-101593","title":"Efficacy and safety of microbiota-targeted therapeutics in autoimmune and inflammatory rheumatic diseases: protocol for a systematic review and meta-analysis of randomised controlled trials","year":2025,"lang":"en","type":"article","venue":"BMJ Open","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bruyère","funders":"Medical Research Council; NIHR Imperial Biomedical Research Centre; Syddansk Universitet; Odense Universitetshospital; Imperial College London; UK Research and Innovation; Parker Institute for Cancer Immunotherapy; Imperial College Healthcare NHS Trust; National Institute for Health and Care Research; Lupus Research Alliance; Oak Foundation","keywords":"Protocol (science); Randomized controlled trial; Alternative medicine; Clinical trial; Rheumatology; MEDLINE; Systematic review","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.09068274,0.00899642,0.03002878,0.01104746,0.003190999,0.009774148,0.006275297,0.009456569,0.05159254],"category_scores_gemma":[0.1542433,0.005614914,0.03706683,0.01279798,0.005241327,0.007970229,0.005380652,0.008937718,0.006981032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01751443,"about_ca_system_score_gemma":0.03380012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005542748,"about_ca_topic_score_gemma":0.008792854,"domain_scores_codex":[0.9149324,0.04338964,0.02392662,0.005751851,0.008900125,0.003099377],"domain_scores_gemma":[0.9414558,0.02374861,0.01565251,0.005867444,0.01136844,0.001907066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.01634491,0.0001795551,0.0007457663,0.916889,0.02835721,0.0002839342,0.0005900234,0.00148594,0.0008750078,0.003592349,0.01748694,0.01316946],"study_design_scores_gemma":[0.1240971,0.003528379,0.006235596,0.5789548,0.1250096,0.0006106477,0.0009584417,0.004697368,0.002866173,0.01888461,0.1334634,0.0006939602],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.0005733508,0.006416135,0.002740896,0.0006336853,0.0007032694,0.9825848,0.005449529,0.0002246372,0.0006737502],"genre_scores_gemma":[0.0008209217,0.001234504,0.002853537,0.0002772584,0.00003807708,0.994074,0.0004686108,0.0000177271,0.0002152641],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.09068274,"threshold_uncertainty_score":0.479582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09521599770841675,"score_gpt":0.4468364893437958,"score_spread":0.3516204916353791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}