{"id":"W4417427569","doi":"10.1016/j.cjca.2025.12.007","title":"Contemporary Controversies Around Medical Ethics of Gene Therapy for Cardiovascular Disease","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Beneficence; Autonomy; Disease; Medical ethics; Psychological intervention; Genetic enhancement; Medical therapy; Unintended consequences","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0654765,0.0004267622,0.001357445,0.002178568,0.008439643,0.01437419,0.003848233,0.03075689,0.006015613],"category_scores_gemma":[0.104592,0.0007226755,0.0007161556,0.002187388,0.0627338,0.006921063,0.004614657,0.03330775,0.001047736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0160495,"about_ca_system_score_gemma":0.01922579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01521914,"about_ca_topic_score_gemma":0.02217294,"domain_scores_codex":[0.9611667,0.02133742,0.001791331,0.00242143,0.0106327,0.002650422],"domain_scores_gemma":[0.8504931,0.1237244,0.004957074,0.00313948,0.01145334,0.006232567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005698685,0.00004138751,0.000452198,0.0001759228,0.00002780914,0.0002488523,0.003895074,0.0002586621,0.0002084838,0.9093006,0.06296093,0.02237299],"study_design_scores_gemma":[0.00009028628,0.00002946919,0.001129732,0.001459918,0.00002871634,0.0004439357,0.00324141,0.0003421892,0.0001642223,0.7649547,0.2280419,0.00007361732],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002980667,0.03063934,0.001643655,0.9313151,0.003035455,0.00001056222,0.00002504951,0.00001182711,0.03033839],"genre_scores_gemma":[0.3664514,0.04177677,0.003739476,0.5428985,0.03860902,0.0001514524,0.00006073358,0.0001223409,0.006190408],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0654765,"threshold_uncertainty_score":0.3462769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03246624601277494,"score_gpt":0.3103901367506989,"score_spread":0.277923890737924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}