{"id":"W4417427609","doi":"10.1016/j.jtct.2025.12.949","title":"Higher HLA-DRB1 Evolutionary Divergence Is Associated with Reduced Relapse and Improved Survival after Matched Unrelated Hematopoietic Cell Transplantation","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Pharmacyclics; Takeda Oncology; U.S. Public Health Service; Health Resources and Services Administration; MorphoSys; Seagen; Pfizer; Incyte; Kiadis Pharma; bluebird bio; Astellas Pharma; Adaptive Biotechnologies; HistoGenetics; Les Laboratories Pierre Fabre; Medac; Jazz Pharmaceuticals; BeiGene; Atara Biotherapeutics; CareDx; Actinium Pharmaceuticals; National Cancer Institute; Gilead Sciences; Sanofi; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; CSL Behring; Bristol-Myers Squibb; AstraZeneca; Gateway for Cancer Research; Swedish Orphan Biovitrum; Omeros Corporation; Vertex Pharmaceuticals; Alexion Pharmaceuticals; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Amgen","keywords":"Hematopoietic stem cell transplantation; Hematopoietic cell; Human leukocyte antigen; Transplantation; Cohort; Myeloid; Sibling; Confidence interval; Disease; Lymphoblastic lymphoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002940197,0.000143491,0.0002579823,0.0003220586,0.0002879309,0.0004693494,0.0002433616,0.0002745856,0.001930051],"category_scores_gemma":[0.000955092,0.00007305985,0.0001731267,0.0004618382,0.0002430583,0.0002169139,0.0003206909,0.0006533499,0.0001793059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001424668,"about_ca_system_score_gemma":0.0001252202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003723011,"about_ca_topic_score_gemma":0.0003711202,"domain_scores_codex":[0.9997955,0.00006651719,0.00001491251,0.00003446985,0.00002829548,0.00006039265],"domain_scores_gemma":[0.9992734,0.0001060448,0.000384046,0.00004751953,0.00002956078,0.0001595263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002303923,0.0003086416,0.9495158,0.00002623671,0.0002739338,0.0007813463,0.0001478976,0.0003444103,0.0336072,0.0002433341,0.0002022867,0.01224503],"study_design_scores_gemma":[0.0000151429,0.0002718567,0.9967383,0.000003890904,0.00003773966,0.001194412,0.0001022469,0.0003230602,0.0009342379,0.0001394674,0.0002349136,0.000004673754],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995988,0.0001143235,0.00005891976,0.000018996,0.000003221003,8.410619e-7,0.00001430881,0.000001786433,0.0001887732],"genre_scores_gemma":[0.9996947,0.0000354357,0.00003311307,0.00002582168,0.00000581998,9.865995e-7,0.00005048668,0.000002585343,0.0001511234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930051,"threshold_uncertainty_score":0.006456673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082043731181578,"score_gpt":0.2319300998007764,"score_spread":0.2211096624889606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}