{"id":"W4417427609","doi":"10.1016/j.jtct.2025.12.949","title":"Higher HLA-DRB1 Evolutionary Divergence Is Associated with Reduced Relapse and Improved Survival after Matched Unrelated Hematopoietic Cell Transplantation","year":2025,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Pharmacyclics; Takeda Oncology; U.S. Public Health Service; Health Resources and Services Administration; MorphoSys; Seagen; Pfizer; Incyte; Kiadis Pharma; bluebird bio; Astellas Pharma; Adaptive Biotechnologies; HistoGenetics; Les Laboratories Pierre Fabre; Medac; Jazz Pharmaceuticals; BeiGene; Atara Biotherapeutics; CareDx; Actinium Pharmaceuticals; National Cancer Institute; Gilead Sciences; Sanofi; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; CSL Behring; Bristol-Myers Squibb; AstraZeneca; Gateway for Cancer Research; Swedish Orphan Biovitrum; Omeros Corporation; Vertex Pharmaceuticals; Alexion Pharmaceuticals; Mallinckrodt Pharmaceuticals; Astellas Pharma US; Amgen","keywords":"Hematopoietic stem cell transplantation; Hematopoietic cell; Human leukocyte antigen; Transplantation; Cohort; Myeloid; Sibling; Confidence interval; Disease; Lymphoblastic lymphoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002329734,0.000381607,0.0004745897,0.0002083503,0.0001928565,0.00004500505,0.00007423478,0.0003005261,0.0003384879],"category_scores_gemma":[0.000002779484,0.0003299856,0.0000872604,0.0004191966,0.0001608857,0.0001815497,0.000004565358,0.0002823602,0.00001060981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005237442,"about_ca_system_score_gemma":0.00009751182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005884991,"about_ca_topic_score_gemma":0.00001163285,"domain_scores_codex":[0.9980514,0.0001671293,0.0005055133,0.0005785053,0.0003612281,0.0003362225],"domain_scores_gemma":[0.9991718,0.0001605343,0.0001294399,0.00023013,0.0001377868,0.00017034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01695762,0.000924679,0.09233362,0.003749869,0.001062579,0.0009424632,0.01994399,0.00001835587,0.8613331,0.0009020339,0.00009317051,0.001738505],"study_design_scores_gemma":[0.02752701,0.0008361173,0.6176538,0.001989549,0.002152031,0.0003071513,0.0007736192,0.000772212,0.3459523,0.0007333831,0.0002869369,0.001015884],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864762,0.002167689,0.007468098,0.0007435139,0.0002145538,0.0009326117,0.0001018544,0.0001681631,0.001727273],"genre_scores_gemma":[0.9884394,0.007429827,0.0005356921,0.0005255363,0.00002014421,0.0000796711,0.0006432928,0.00004828951,0.002278169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5253202,"threshold_uncertainty_score":0.9999152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082043731181578,"score_gpt":0.2319300998007764,"score_spread":0.2211096624889606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}