{"id":"W4417429109","doi":"10.1038/d41586-025-03608-1","title":"A universal flu vaccine has proved challenging — could it finally be possible?","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"World Federation of Science Journalists","funders":"","keywords":"Influenza vaccine; Bird flu; Emerging technologies; Vaccination; Live attenuated influenza vaccine; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02372461,0.000656845,0.001617249,0.0004450376,0.001537162,0.00407334,0.001831611,0.007068219,0.02844975],"category_scores_gemma":[0.03100729,0.0002796039,0.0014419,0.000508732,0.004483311,0.009181791,0.002655659,0.006772657,0.003864175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003066431,"about_ca_system_score_gemma":0.01296968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006172805,"about_ca_topic_score_gemma":0.006570129,"domain_scores_codex":[0.9957059,0.001991652,0.000315409,0.0003338154,0.0005604251,0.001092956],"domain_scores_gemma":[0.975314,0.01288845,0.001833376,0.001574463,0.004657539,0.003732244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005218365,0.001161414,0.007368836,0.004342628,0.001005599,0.0008268882,0.0007221848,0.000870659,0.008697728,0.1785088,0.4105853,0.3806917],"study_design_scores_gemma":[0.0006778358,0.003313047,0.007367585,0.003958035,0.0006447668,0.0005830079,0.003247725,0.0003694806,0.004655537,0.1071079,0.8679544,0.0001206475],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.008913866,0.1205659,0.002407328,0.8248438,0.02710977,0.0000962216,0.0006223332,0.000136334,0.01530434],"genre_scores_gemma":[0.2442684,0.1381709,0.0135242,0.5454158,0.03062224,0.0005014033,0.001249633,0.0001803061,0.02606714],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02844975,"threshold_uncertainty_score":0.1254693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05005787252579025,"score_gpt":0.3754087205858318,"score_spread":0.3253508480600416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}