{"id":"W4417434441","doi":"10.1021/acs.joc.5c02743","title":"Simplified Protocol Conditions for the Gold-Catalyzed Hydrofluorination of Terminal Aliphatic Alkynes","year":2025,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Catalytic Alkyne Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Umicore; Natural Sciences and Engineering Research Council of Canada; Fonds Wetenschappelijk Onderzoek; Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Terminal (telecommunication); Protocol (science); Solvent; Halogenation; Process (computing)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004570298,0.0001600102,0.00026721,0.00003331841,0.0001761407,0.00002816419,0.0006482888,0.0001001324,0.0008624498],"category_scores_gemma":[0.0006206708,0.0001006014,0.0002031697,0.0002399001,0.0001962196,0.000100935,0.00008106467,0.0003018444,0.000003288855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001785155,"about_ca_system_score_gemma":0.0004214053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000812358,"about_ca_topic_score_gemma":0.000002767519,"domain_scores_codex":[0.9987516,0.00001341499,0.0006883228,0.0001059883,0.0002678695,0.0001728055],"domain_scores_gemma":[0.997215,0.001099254,0.0007875707,0.0005066147,0.0003441942,0.00004738673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001368656,0.0001362228,0.00003760171,0.0005012875,0.0002724952,0.00000169026,0.0001387095,0.000017891,0.9949667,0.00005590268,0.002778537,0.0009560386],"study_design_scores_gemma":[0.001536973,0.00001261721,0.0001000805,0.0001945144,0.0005899865,0.0003751878,0.001176391,0.0002330097,0.98866,0.001090694,0.00593238,0.00009816547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563151,0.000399804,0.006084771,0.007079655,0.0003646846,0.01443892,0.0002160861,0.00009014738,0.01501085],"genre_scores_gemma":[0.993378,0.00001570254,0.00005236505,0.00003065703,0.0002796886,0.001688004,0.0000174559,0.00002330815,0.004514795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03706294,"threshold_uncertainty_score":0.944322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219597651826875,"score_gpt":0.3004325367971103,"score_spread":0.2882365602788415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}