{"id":"W4417436058","doi":"10.1001/jamadermatol.2025.4950","title":"Vixarelimab in Patients With Prurigo Nodularis","year":2025,"lang":"en","type":"article","venue":"JAMA Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"LEO Pharma; Galderma; Genentech; Kiniksa Pharmaceuticals; Regeneron Pharmaceuticals; Sanofi; Eli Lilly and Company; GlaxoSmithKline; Celldex Therapeutics; Amgen","keywords":"Prurigo nodularis; Placebo; Randomized controlled trial; Quality of life (healthcare); Clinical trial; Rating scale; Severity of illness","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003248097,0.0001417795,0.0004076424,0.0003011278,0.00004771444,0.00001096998,0.0001006341,0.0002333727,0.00009599084],"category_scores_gemma":[0.0001461769,0.0001125796,0.00004756836,0.000315356,0.0001439561,0.00007473559,0.00004962117,0.0002564633,0.00009260516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003474837,"about_ca_system_score_gemma":0.0001489918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000122437,"about_ca_topic_score_gemma":0.00001734366,"domain_scores_codex":[0.9989922,0.00007773548,0.0002664005,0.0002535544,0.0001115332,0.0002985784],"domain_scores_gemma":[0.9993811,0.00009235497,0.00004989213,0.0003154002,0.00008993251,0.0000713651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008300554,0.0005073914,0.9653205,0.0001290023,0.00007174238,0.0005863162,0.00004572677,0.000001201239,0.000003587046,0.001250387,0.03026782,0.0009862423],"study_design_scores_gemma":[0.007443306,0.00004106715,0.9753556,0.0001229007,0.0000758458,0.0002020113,0.00003298953,0.00005457697,0.0003133503,0.0004558595,0.01579962,0.0001028525],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695545,0.0004618276,0.00008894708,0.008183357,0.0001505047,0.0003655599,0.000006236212,0.00007176694,0.02111733],"genre_scores_gemma":[0.9936732,0.000009823953,0.0002626202,0.005626051,0.000009014017,0.00003976602,0.00007194683,0.00001087177,0.0002966809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02411875,"threshold_uncertainty_score":0.4590863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002979455070905239,"score_gpt":0.2302415642247358,"score_spread":0.2272621091538306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}