{"id":"W4417436194","doi":"10.3390/cancers17244025","title":"Drug-Induced Partial Immunosuppression for Preclinical Human Tumor Xenograft Models","year":2025,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Ministry of Health of the Russian Federation; Ministry of Science and Higher Education of the Russian Federation; Russian Science Foundation","keywords":"Immunosuppression; Immune system; Human immunodeficiency virus (HIV); Tumor cells; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006370398,0.0007661712,0.0004928015,0.0005757095,0.0002061473,0.0003959462,0.0004890448,0.0003612329,0.003975458],"category_scores_gemma":[0.0001912078,0.0001791504,0.0005120282,0.0003820383,0.0002733386,0.0003512251,0.0002185917,0.001500459,0.001038129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000283479,"about_ca_system_score_gemma":0.0003182413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002657426,"about_ca_topic_score_gemma":0.0006965954,"domain_scores_codex":[0.9997409,0.00006815891,0.00002558649,0.00004410606,0.00007307503,0.00004810001],"domain_scores_gemma":[0.9997454,0.00005318191,0.00007317139,0.00005731579,0.0000295941,0.00004128065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005733984,0.0008097288,0.0002878311,0.0001805053,0.00001704311,0.0000464725,0.00002463607,0.0003146828,0.9910722,0.0002163976,0.0002758358,0.006181345],"study_design_scores_gemma":[0.0001433435,0.007089309,0.002971022,0.00003538523,0.00005898305,0.0004363893,0.00002224914,0.001599565,0.9802449,0.00008131166,0.007308581,0.000008766396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9310963,0.01146574,0.04485652,0.0004344671,0.0004596554,0.001876187,0.003598319,0.0007567878,0.005456069],"genre_scores_gemma":[0.9390207,0.008781788,0.03920749,0.0001511198,0.0001068368,0.002575359,0.004435108,0.0001423495,0.005579269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003975458,"threshold_uncertainty_score":0.01329923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04074082583525031,"score_gpt":0.3895054973858791,"score_spread":0.3487646715506288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}