{"id":"W4417436333","doi":"10.1001/jama.2025.21738","title":"Valacyclovir Treatment of Early Symptomatic Alzheimer Disease","year":2025,"lang":"en","type":"article","venue":"JAMA","topic":"Hepatitis C virus research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrasource","funders":"","keywords":"Alzheimer's disease; Disease; MEDLINE; Central nervous system disease; Degenerative disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001064672,0.0004779454,0.001199929,0.0002735581,0.0002103341,0.0005187214,0.0003042931,0.0007702322,0.002497185],"category_scores_gemma":[0.001243062,0.0001674696,0.0005710661,0.0002226033,0.0002832837,0.0002983203,0.0001890446,0.001050514,0.0001759901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000309389,"about_ca_system_score_gemma":0.0004260076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004916914,"about_ca_topic_score_gemma":0.001025295,"domain_scores_codex":[0.9996886,0.0001684061,0.00003578082,0.00003875668,0.00003263483,0.00003577378],"domain_scores_gemma":[0.9996437,0.0001655995,0.00007193669,0.00001299535,0.00002276693,0.00008297996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6133039,0.007376161,0.005299753,0.005713429,0.001310904,0.0002783793,0.0001662186,0.0003793497,0.008370096,0.0004118886,0.00191289,0.3554771],"study_design_scores_gemma":[0.7646641,0.1909178,0.02662847,0.001360669,0.001521924,0.0007728107,0.0001419327,0.0006885107,0.003461884,0.0007121316,0.009098643,0.00003117443],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9008639,0.09205032,0.0003484414,0.0005626298,0.0006264332,0.001031895,0.0002641853,0.00004842641,0.004203709],"genre_scores_gemma":[0.9854441,0.01133397,0.0006034702,0.0004537246,0.0003261051,0.0005569503,0.0001543061,0.000003239038,0.001123954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002497185,"threshold_uncertainty_score":0.008353949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03530346021686909,"score_gpt":0.3553105710513806,"score_spread":0.3200071108345115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}