{"id":"W4417439551","doi":"10.1038/s44328-026-00098-7","title":"Label-free optical observation of disordered-to-ordered transitions in single intrinsically disordered proteins","year":2025,"lang":"en","type":"article","venue":"npj Biosensing","topic":"Advanced Fluorescence Microscopy Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Biotechnology and Biological Sciences Research Council; Wolfson Foundation; Academy of Medical Sciences; UK-India Education and Research Initiative; Scheme for Promotion of Academic and Research Collaboration; Directorate for Biological Sciences; Royal Society","keywords":"Intrinsically disordered proteins; Optical tweezers; Conformational change; Protein structure; Globular protein; Limiting; Conformational ensembles; Förster resonance energy transfer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009404944,0.0001416833,0.0001080881,0.0001368341,0.0001232705,0.0001559653,0.0002645318,0.0002689781,0.0005872782],"category_scores_gemma":[0.0001975637,0.00009713634,0.00006985691,0.00009314682,0.0003389762,0.0002484737,0.0002361626,0.000360752,0.000113549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002685594,"about_ca_system_score_gemma":0.000106178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004007889,"about_ca_topic_score_gemma":0.0006541637,"domain_scores_codex":[0.9999322,0.000007078874,0.000002824705,0.00002382792,0.00002088321,0.00001314533],"domain_scores_gemma":[0.9998752,0.00005292989,0.00003463839,0.00001382091,0.00001144509,0.0000119623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001598687,0.000008448282,0.00009178944,0.00001663569,0.000001496978,0.00001808034,0.00001706445,0.0001162971,0.9986103,0.0001122141,0.00002346754,0.0009681662],"study_design_scores_gemma":[0.000006835994,0.00005066443,0.001764756,0.00000240417,0.000003133094,0.00006139371,0.00002690665,0.005617379,0.9917724,0.00009454292,0.0005934127,0.000006212845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879125,0.0003070995,0.01051709,0.00008146116,0.00001625018,0.00001106519,0.00008528495,0.00008900122,0.000980344],"genre_scores_gemma":[0.9885209,0.0002814935,0.009890478,0.00005585195,0.00001150934,0.00002813871,0.00006804644,0.00001885286,0.001124846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005872782,"threshold_uncertainty_score":0.001964688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147044502012746,"score_gpt":0.2756430079230495,"score_spread":0.2641725629029221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}