{"id":"W4417444435","doi":"10.64898/2025.12.15.25342309","title":"Interactive Effects of Telomere Length and Genetic Variants on Alzheimer Disease Risk Across Multiple Ancestral Populations","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Canadian Institutes of Health Research; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Uniformed Services University of the Health Sciences; IXICO; Karl-Franzens-Universität Graz; H. Lundbeck A/S; Medical Research Council; Servier; National Institutes of Health; Oesterreichische Nationalbank; Österreichische Forschungsförderungsgesellschaft; University of Southern California; Foundation for the National Institutes of Health; Eisai; Ministry of Science, ICT and Future Planning; University of Toronto; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute on Minority Health and Health Disparities; European Commission; Genentech; Erasmus Medisch Centrum; Medizinische Universität Graz; Austrian Science Fund; National Human Genome Research Institute; Russian Foundation for Basic Research; ZonMw; Pfizer; University of Washington; EU Joint Programme – Neurodegenerative Disease Research; Texas Alzheimer's Research and Care Consortium; Vanderbilt University; Northern California Institute for Research and Education; Case Western Reserve University; Biogen; University of Miami; BioClinica; Broad Institute; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Bristol-Myers Squibb; Eli Lilly and Company; National Institute on Deafness and Other Communication Disorders; F. Hoffmann-La Roche; Wellcome Trust; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Alzheimer's Association; U.S. Department of Health and Human Services","keywords":"Genetic variants; Telomere; Alzheimer's disease; Disease; Genetic variation; Allele; Genome-wide association study","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002335768,0.0006923965,0.0006678117,0.001133459,0.0008153473,0.001184206,0.0007291433,0.0007221193,0.00387798],"category_scores_gemma":[0.004872709,0.0003551012,0.001673328,0.001490743,0.0005921103,0.0004839115,0.001265966,0.001111163,0.0002025533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003254557,"about_ca_system_score_gemma":0.0003404639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007175099,"about_ca_topic_score_gemma":0.007217731,"domain_scores_codex":[0.9972025,0.001066455,0.0001690909,0.001109267,0.0001869262,0.0002658988],"domain_scores_gemma":[0.9965286,0.001732946,0.0005574133,0.0006454472,0.0001851247,0.0003505335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001888478,0.00008018,0.9770064,0.00006385914,0.004325321,0.0004440861,0.0003803298,0.0009928797,0.006950754,0.0006018793,0.000334964,0.006930913],"study_design_scores_gemma":[0.00004104299,0.000197143,0.9939718,0.00002365577,0.001319461,0.0002995201,0.000199229,0.002135127,0.0004641854,0.0008009708,0.0005300264,0.00001797746],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963087,0.0006173381,0.001555475,0.0001382966,0.00002205338,0.000006789178,0.000787629,0.00004530504,0.0005183031],"genre_scores_gemma":[0.9985434,0.0001036919,0.0006564429,0.00004237123,0.00001411753,0.00001226226,0.0003390216,0.00001714707,0.0002715438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007175099,"threshold_uncertainty_score":0.01426667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03528817129883391,"score_gpt":0.3351665252307784,"score_spread":0.2998783539319445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}