{"id":"W4417445990","doi":"10.20944/preprints202509.1567.v2","title":"<p class=\"MDPI12title\"><span lang=\"EN-CA\" style=\"mso-bidi-font-size: 18.0pt; mso-ansi-language: EN-CA;\">MRCKα/CDC42BPA Is a Suppressor of GEF-H1/RhoA/MRTF Signaling in Tubular Cells","year":2025,"lang":"","type":"preprint","venue":"Preprints.org","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Gene silencing; SGK1; Transcription factor; Fibrosis; Kidney; Myosin; RHOA; Gene expression; Chromatin immunoprecipitation; Cytokine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","open_science","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.004592743,0.002480638,0.003224181,0.001424846,0.0003422095,0.0001878236,0.004634432,0.003565178,0.02376905],"category_scores_gemma":[0.004506996,0.002902691,0.001741038,0.001408598,0.0009460888,0.00007283129,0.01087074,0.004274656,0.002210205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001006682,"about_ca_system_score_gemma":0.002415441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001783919,"about_ca_topic_score_gemma":0.0006710536,"domain_scores_codex":[0.9823331,0.003324199,0.003399517,0.005864131,0.002089938,0.002989143],"domain_scores_gemma":[0.9882897,0.001437954,0.001453221,0.006351225,0.001460654,0.001007235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001396496,0.001317805,0.0401797,0.002707044,0.001902305,0.0003457286,0.004671014,0.000830491,0.943381,0.0001376077,0.001671696,0.001459163],"study_design_scores_gemma":[0.003637529,0.0003388198,0.03043299,0.001293144,0.0004896334,0.00003688902,0.001125076,0.000761411,0.9143621,0.0002092937,0.04501175,0.002301324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685351,0.00631953,0.0006959657,0.001093399,0.001378413,0.00452343,0.00259149,0.0001212565,0.01474138],"genre_scores_gemma":[0.9708365,0.003425288,0.0005904051,0.0003147315,0.0009156492,0.0007495572,0.0007794518,0.0003391412,0.02204934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04334006,"threshold_uncertainty_score":0.998793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04439788685798512,"score_gpt":0.344887295858945,"score_spread":0.3004894090009599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}