{"id":"W4417445990","doi":"10.20944/preprints202509.1567.v2","title":"<p class=\"MDPI12title\"><span lang=\"EN-CA\" style=\"mso-bidi-font-size: 18.0pt; mso-ansi-language: EN-CA;\">MRCKα/CDC42BPA Is a Suppressor of GEF-H1/RhoA/MRTF Signaling in Tubular Cells","year":2025,"lang":"","type":"preprint","venue":"Preprints.org","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Gene silencing; SGK1; Transcription factor; Fibrosis; Kidney; Myosin; RHOA; Gene expression; Chromatin immunoprecipitation; Cytokine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004446486,0.001911327,0.002483703,0.001779528,0.0009052089,0.00339266,0.002832085,0.001427841,0.7408713],"category_scores_gemma":[0.001135792,0.001514069,0.001082044,0.001047458,0.0007414896,0.002036694,0.002547969,0.002851099,0.6523373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001602386,"about_ca_system_score_gemma":0.0008593517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001996737,"about_ca_topic_score_gemma":0.002362726,"domain_scores_codex":[0.9992612,0.0000510805,0.00005755032,0.0001507852,0.000312888,0.0001664735],"domain_scores_gemma":[0.9991953,0.0001779957,0.00006213404,0.0001905526,0.0001142814,0.0002597235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001677952,0.0007549695,0.0006226099,0.001934779,0.0001281591,0.0003528511,0.0003103061,0.0005099335,0.1903096,0.005136556,0.6684636,0.1297987],"study_design_scores_gemma":[0.0002608426,0.0001439345,0.002968097,0.000130746,0.00003254696,0.000254867,0.0000566735,0.0009500221,0.1679296,0.0005897702,0.8266056,0.00007737798],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.02060899,0.003961042,0.03537554,0.003347923,0.004925207,0.0021027,0.2071787,0.1900671,0.5324328],"genre_scores_gemma":[0.05797369,0.002573062,0.01393868,0.0009460793,0.0003398126,0.00165943,0.07947347,0.0900658,0.75303],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.2591287,"threshold_uncertainty_score":0.3696156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04439788685798512,"score_gpt":0.344887295858945,"score_spread":0.3004894090009599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}