{"id":"W4417449208","doi":"10.3389/fimmu.2025.1665811","title":"SMAC mimetics sensitize HIV-infected cells to oncolytic virus-mediated death","year":2025,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Research Institute; Canadian Institutes of Health Research; University of Ottawa","keywords":"Oncolytic virus; Programmed cell death; Necroptosis; Apoptosis; Caspase; Tumor necrosis factor alpha; Cancer cell; Interferon; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341972,0.0001971203,0.0002142934,0.0001564119,0.0001044002,0.0002313365,0.0001143641,0.0002506392,0.001232319],"category_scores_gemma":[0.00009374107,0.00008660521,0.0001355601,0.0001032103,0.0001373059,0.0001856324,0.0001489832,0.0004954984,0.0002423567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396494,"about_ca_system_score_gemma":0.00008826175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001247379,"about_ca_topic_score_gemma":0.0002227305,"domain_scores_codex":[0.999925,0.00001771711,0.00000816594,0.00001085027,0.00001729044,0.00002092914],"domain_scores_gemma":[0.9999429,0.00001987659,0.00001367887,0.000007999057,0.000005321878,0.00001017952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001259697,0.00003095846,0.0001027225,0.00004231096,0.000003686947,0.00003326506,0.00001592943,0.00006580197,0.9977937,0.0001034405,0.00003939696,0.001642848],"study_design_scores_gemma":[0.0000169308,0.0006575835,0.001312885,0.000005696374,0.000005811661,0.0001758068,0.00001315661,0.0003544026,0.9954185,0.00004850116,0.001988339,0.000002329397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906894,0.004150019,0.002343656,0.0001011117,0.000039125,0.00005641069,0.0001454652,0.00006908518,0.002405655],"genre_scores_gemma":[0.9941789,0.001826719,0.002266933,0.0000671454,0.00001484813,0.00004261018,0.0001754109,0.000009440145,0.001418085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001232319,"threshold_uncertainty_score":0.004122555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006300931170182184,"score_gpt":0.2324520218279181,"score_spread":0.2261510906577359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}