{"id":"W4417455715","doi":"10.1093/braincomms/fcaf491","title":"Microstructure and gene expression influence gyrification in amyotrophic lateral sclerosis","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Natural Science Foundation of Hunan Province; National Key Research and Development Program of China; Science and Technology Development Fund; National Natural Science Foundation of China","keywords":"Gyrification; Amyotrophic lateral sclerosis; Fractional anisotropy; White matter; Corticospinal tract; Grey matter; Cerebral cortex; Motor cortex; Human brain","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115744,0.0001676638,0.0001706779,0.0003043343,0.0001134762,0.0001986348,0.00005701128,0.0001341789,0.0005525585],"category_scores_gemma":[0.0003393421,0.00007469044,0.0001242491,0.0003029217,0.0002186985,0.00007440559,0.0001190097,0.0001139931,0.0000984482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001348777,"about_ca_system_score_gemma":0.00007308654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001149425,"about_ca_topic_score_gemma":0.001449769,"domain_scores_codex":[0.9999381,0.00001178191,0.000005404886,0.00002355084,0.00001129435,0.000009807802],"domain_scores_gemma":[0.9998533,0.00002868028,0.00008460463,0.000008830065,0.00001289599,0.00001170078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001381194,0.00004905524,0.3678164,0.00008681093,0.0001848163,0.0006134236,0.0004451169,0.0006563481,0.619666,0.0001462127,0.0001501143,0.008804521],"study_design_scores_gemma":[0.000005938486,0.0000697811,0.991663,0.000003459233,0.00002524308,0.0002777704,0.00007981103,0.0004140837,0.007159831,0.0001397905,0.0001581175,0.000003151915],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993879,0.0001410987,0.0002172434,0.00001232154,9.474572e-7,0.000001925927,0.0001238377,0.000006631816,0.0001081054],"genre_scores_gemma":[0.9995949,0.00004413386,0.0001518158,0.000005919582,0.000001220475,0.000004190113,0.00009181871,0.000002231038,0.0001037892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001149425,"threshold_uncertainty_score":0.00228548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03663837449007751,"score_gpt":0.3270968368663438,"score_spread":0.2904584623762663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}