{"id":"W4417461958","doi":"10.1186/s12885-025-15440-x","title":"Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes","year":2025,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; School of Public Health, Imperial College London; Cancer Council Victoria; National Institutes of Health; Österreichische Forschungsförderungsgesellschaft; Cancerfonden; Federación Española de Enfermedades Raras; Generalitat de Catalunya; Fundación Científica Asociación Española Contra el Cáncer; Bundesministerium für Bildung und Forschung; Imperial College London; Centres de Recerca de Catalunya; Deutsche Forschungsgemeinschaft; Fred Hutchinson Cancer Research Center; Deutsches Krebsforschungszentrum; Emory University; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Health and Medical Research Council; Australian Institute of Health and Welfare, Australian Government; American Cancer Society; NIHR Imperial Biomedical Research Centre; Centre International de Recherche sur le Cancer; Instituto de Salud Carlos III; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Office of Research Infrastructure Programs, National Institutes of Health; Junta de Castilla y León; U.S. Department of Health and Human Services; Herzfelder'sche Familienstiftung; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública","keywords":"Surgical oncology; Colorectal cancer; Mutation; Survival analysis; Overall survival; Gene; Drug; Drug resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004221702,0.0001524862,0.0004483328,0.0001080173,0.00007612133,0.00001031856,0.00003949087,0.00004877942,0.00004152596],"category_scores_gemma":[0.00002107161,0.0001152782,0.00005904064,0.0002006806,0.00009083991,0.00003998534,0.00005352194,0.00005253577,0.000001465739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001853237,"about_ca_system_score_gemma":0.0003124474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009298013,"about_ca_topic_score_gemma":0.001562213,"domain_scores_codex":[0.9992256,0.00002864764,0.0002527464,0.0002409243,0.0001203442,0.0001317649],"domain_scores_gemma":[0.9995965,0.0000477299,0.00009227676,0.0001081968,0.000108552,0.00004677658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000599269,0.0000904928,0.7043245,0.0001926034,0.0002450845,0.000008104928,0.001059029,0.000002544793,0.2855084,0.0001686192,0.00002300563,0.007778271],"study_design_scores_gemma":[0.001571476,0.0001871135,0.9680477,0.000104667,0.0001528081,0.000001112352,0.0002209613,0.0001165825,0.02855621,0.00005878344,0.0008830315,0.00009952605],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953877,0.002931499,0.00007536283,0.0001583853,0.0002980584,0.000450295,0.0000400417,0.00003530041,0.0006233059],"genre_scores_gemma":[0.9981169,0.0008661212,0.00008677869,0.00009894845,0.00004519754,0.0001330346,0.00005146123,0.00001255501,0.0005890019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2637232,"threshold_uncertainty_score":0.4700908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01936442534368724,"score_gpt":0.2790976558254351,"score_spread":0.2597332304817478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}