{"id":"W4417461958","doi":"10.1186/s12885-025-15440-x","title":"Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes","year":2025,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; School of Public Health, Imperial College London; Cancer Council Victoria; National Institutes of Health; Österreichische Forschungsförderungsgesellschaft; Cancerfonden; Federación Española de Enfermedades Raras; Generalitat de Catalunya; Fundación Científica Asociación Española Contra el Cáncer; Bundesministerium für Bildung und Forschung; Imperial College London; Centres de Recerca de Catalunya; Deutsche Forschungsgemeinschaft; Fred Hutchinson Cancer Research Center; Deutsches Krebsforschungszentrum; Emory University; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Health and Medical Research Council; Australian Institute of Health and Welfare, Australian Government; American Cancer Society; NIHR Imperial Biomedical Research Centre; Centre International de Recherche sur le Cancer; Instituto de Salud Carlos III; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Office of Research Infrastructure Programs, National Institutes of Health; Junta de Castilla y León; U.S. Department of Health and Human Services; Herzfelder'sche Familienstiftung; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública","keywords":"Surgical oncology; Colorectal cancer; Mutation; Survival analysis; Overall survival; Gene; Drug; Drug resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002075975,0.0001961926,0.0002772707,0.001368799,0.0001780107,0.0003572595,0.0001650527,0.0002076365,0.001355034],"category_scores_gemma":[0.0008380485,0.00007492906,0.0002504713,0.00105121,0.0002020005,0.0001641657,0.0002668918,0.0002043449,0.0001205402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001766902,"about_ca_system_score_gemma":0.0001775588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249045,"about_ca_topic_score_gemma":0.001582594,"domain_scores_codex":[0.9998025,0.00004222156,0.00001894463,0.0000692249,0.00003239018,0.00003463928],"domain_scores_gemma":[0.9993069,0.0002664838,0.0002547792,0.00004106313,0.00005193846,0.00007881079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004097981,0.00002155041,0.950965,0.00008615175,0.0001896577,0.0003445868,0.00004427563,0.0004872016,0.03847754,0.00007872446,0.0001098366,0.008785561],"study_design_scores_gemma":[0.000005646656,0.00006060794,0.9945673,0.000006474867,0.00008700137,0.0009624839,0.00007171855,0.0007113207,0.003088296,0.0001580672,0.0002778277,0.000003319513],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975682,0.0008094165,0.000572511,0.00004461987,0.000002174884,0.000003304306,0.0007655132,0.00001141385,0.000222912],"genre_scores_gemma":[0.9990706,0.0001381766,0.0002705018,0.00001226643,0.000003868474,0.000002856956,0.00043953,0.000002745389,0.00005951084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368799,"threshold_uncertainty_score":0.004532993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01936442534368724,"score_gpt":0.2790976558254351,"score_spread":0.2597332304817478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}