{"id":"W4417464214","doi":"10.2196/76815","title":"Efficacy, Safety, and Economic Impact of Cytisinicline Maintenance Therapy in Patients Who Are Candidates for Smoking Cessation: Protocol for a Phase IV, Multicenter, Randomized, Open-Label, Controlled, Parallel Clinical Trial (CITISILONG Trial)","year":2025,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Protocol (science); Clinical trial; Economic impact analysis; Phase (matter); Economic evaluation; Phases of clinical research","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02156147,0.004177667,0.005968077,0.001532604,0.002487817,0.002198927,0.002963512,0.004735501,0.03122708],"category_scores_gemma":[0.01510544,0.001453001,0.004123246,0.00202656,0.002803747,0.002221805,0.001337229,0.005717565,0.007016904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00335626,"about_ca_system_score_gemma":0.01088471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0011622,"about_ca_topic_score_gemma":0.002194615,"domain_scores_codex":[0.9869459,0.008920879,0.001129784,0.0009045334,0.001025088,0.00107373],"domain_scores_gemma":[0.990386,0.001426068,0.002207751,0.001432062,0.002335549,0.002212547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9462783,0.02102455,0.001132607,0.004180901,0.0005946119,0.0001409241,0.0001913066,0.001308421,0.003672884,0.001264779,0.005729935,0.01448073],"study_design_scores_gemma":[0.9054459,0.06812402,0.00336874,0.0008195013,0.0004760664,0.00006666159,0.00009414714,0.00102387,0.001318616,0.0008777501,0.01832532,0.00005940392],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.009905196,0.0003078443,0.00117621,0.0002389478,0.0002402619,0.9857961,0.001047843,0.00005738844,0.001230151],"genre_scores_gemma":[0.008261587,0.0002410598,0.002674168,0.0002246543,0.0001015668,0.9872087,0.0005826314,0.000007714383,0.0006980017],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03122708,"threshold_uncertainty_score":0.1140293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2935893322851838,"score_gpt":0.6180160672698755,"score_spread":0.3244267349846917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}