{"id":"W4417466436","doi":"10.1016/j.jconrel.2025.114557","title":"Enzyme-coupled polymersome microreactor for point-of-care blood urea sensing","year":2025,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Analytical Chemistry and Sensors","field":"Chemical Engineering","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Université de Montréal; Agence Nationale de la Recherche; Région Auvergne-Rhône-Alpes; Canada Foundation for Innovation","keywords":"Polymersome; Microreactor; Urea; Analyte; Membrane; Fluorophore; Polyethylene glycol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004666521,0.000575962,0.0005585214,0.0002063585,0.0001920853,0.0003756272,0.0008491161,0.0008094223,0.001190619],"category_scores_gemma":[0.00046266,0.00025186,0.0003384213,0.0001801977,0.000251302,0.0006147915,0.0003494036,0.0006939192,0.0005771569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004976912,"about_ca_system_score_gemma":0.0004011669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005850624,"about_ca_topic_score_gemma":0.001397904,"domain_scores_codex":[0.9995685,0.00006120217,0.00001956118,0.0001367811,0.0001564072,0.00005749856],"domain_scores_gemma":[0.9997695,0.0000804274,0.00005462956,0.00001957911,0.00004875931,0.00002718921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006286747,0.00001377352,0.00005220866,0.00004393598,0.000005131536,0.00002434643,0.00001069269,0.00004641028,0.9964679,0.00008068079,0.0001164631,0.003075588],"study_design_scores_gemma":[0.000007103419,0.0001338476,0.0004357028,0.000003767108,0.000009902759,0.0000906474,0.00000728031,0.001843872,0.9962215,0.00001923741,0.001215647,0.00001151996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8130451,0.00843657,0.1700868,0.0009200823,0.0006140976,0.0002375801,0.0009822164,0.002001742,0.003675755],"genre_scores_gemma":[0.8920108,0.002359555,0.09500758,0.0005816623,0.0001488137,0.0002335993,0.0003083803,0.00008309451,0.009266531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001190619,"threshold_uncertainty_score":0.00398308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004912979529679205,"score_gpt":0.2322718914595649,"score_spread":0.2273589119298857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}