{"id":"W4417466674","doi":"10.3390/vaccines13121257","title":"Immunogenicity of Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Versus Non-Adjuvanted SARS-CoV-2 Spike Booster Vaccines in Young and Aged Balb/c Mice","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Government of Canada","keywords":"Immunogenicity; Immune system; Antibody; Antigen; Heterologous; Priming (agriculture); Vaccination; Immunization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006306679,0.0005745445,0.001254043,0.001446257,0.0001264021,0.00003977574,0.0005023042,0.0003343602,0.00001936689],"category_scores_gemma":[0.0009579878,0.0005035307,0.0002473595,0.002013409,0.0001817381,0.0002553037,0.0006048964,0.0007360743,0.00002507071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001635636,"about_ca_system_score_gemma":0.0003743781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00595115,"about_ca_topic_score_gemma":0.009246266,"domain_scores_codex":[0.9964385,0.0002012675,0.001069204,0.0008710902,0.0005214846,0.0008984404],"domain_scores_gemma":[0.9976879,0.000647176,0.0002235378,0.0008830497,0.0004905025,0.00006777265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01185589,0.0002884934,0.3004573,0.0005766823,0.0002928631,0.0001273294,0.0009125908,4.189472e-7,0.6830786,0.00002984038,0.0003543866,0.002025628],"study_design_scores_gemma":[0.01884817,0.0005074011,0.3652439,0.0007161004,0.0001695729,0.00005189501,0.0004565359,0.0009936587,0.611087,0.0001351636,0.00142803,0.0003626132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928814,0.002704868,0.0001115167,0.0009907485,0.0006126835,0.001319778,0.0000413027,0.0001356896,0.001202034],"genre_scores_gemma":[0.996064,0.0001736914,0.0002352613,0.003058445,0.0001267295,0.00007924948,0.00003393163,0.00006806511,0.0001606024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07199163,"threshold_uncertainty_score":0.9997416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02729325433311374,"score_gpt":0.3331410061552946,"score_spread":0.3058477518221808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}