{"id":"W4417466674","doi":"10.3390/vaccines13121257","title":"Immunogenicity of Sulfated Lactosyl Archaeol Archaeosome-Adjuvanted Versus Non-Adjuvanted SARS-CoV-2 Spike Booster Vaccines in Young and Aged Balb/c Mice","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Government of Canada","keywords":"Immunogenicity; Immune system; Antibody; Antigen; Heterologous; Priming (agriculture); Vaccination; Immunization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005261944,0.0009209452,0.0005747196,0.0006508351,0.0001940801,0.0003667554,0.000383322,0.0008350287,0.0009412084],"category_scores_gemma":[0.0002816278,0.0003309421,0.0004951608,0.0001599741,0.0004200597,0.0006216663,0.0001940795,0.001757931,0.0003794015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005268523,"about_ca_system_score_gemma":0.0003854767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009044838,"about_ca_topic_score_gemma":0.001265591,"domain_scores_codex":[0.9996265,0.00004584634,0.00003232733,0.00009620465,0.00007715479,0.0001220638],"domain_scores_gemma":[0.9993452,0.00005080388,0.0002646023,0.00004635063,0.00007413785,0.0002188974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004415439,0.001510465,0.001024583,0.00008182039,0.00002438584,0.00006669559,0.00007679602,0.0002401786,0.9900591,0.00006224472,0.000130685,0.002307673],"study_design_scores_gemma":[0.0006786601,0.07103906,0.03341481,0.00006181083,0.0001923112,0.0005016798,0.0002110255,0.001921247,0.8898504,0.0001225678,0.001954345,0.00005207417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978581,0.0005699138,0.000442488,0.00005758456,0.00005264483,0.000060723,0.0004387917,0.00004372567,0.0004759263],"genre_scores_gemma":[0.9933705,0.0009234745,0.001268481,0.0002209012,0.0000559812,0.0001693715,0.0009460631,0.00002806912,0.003017082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009412084,"threshold_uncertainty_score":0.003822565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02729325433311374,"score_gpt":0.3331410061552946,"score_spread":0.3058477518221808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}