{"id":"W4417468282","doi":"10.1038/s41598-025-33177-2","title":"Integrative biochemical and computational analysis of leflunomide-induced redox alterations in Nauphoeta cinerea","year":2025,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Herbal Medicine Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Princess Nourah Bint Abdulrahman University","keywords":"Dihydroorotate dehydrogenase; Leflunomide; Oxidative stress; Lipid peroxidation; Glutathione; Toxicity; Hormesis; Aché","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733713,0.0007605905,0.0009714702,0.0006008816,0.0004746092,0.0007239204,0.0006902717,0.0008491417,0.002429581],"category_scores_gemma":[0.0002889522,0.0003138525,0.001402669,0.0004959787,0.0001928469,0.0004703583,0.0003159085,0.0004515071,0.0003242491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005513264,"about_ca_system_score_gemma":0.0006339351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01303051,"about_ca_topic_score_gemma":0.01171265,"domain_scores_codex":[0.99994,0.000007964642,0.000003673498,0.00001926281,0.00001365601,0.00001531571],"domain_scores_gemma":[0.9999262,0.00002888903,0.0000111551,0.000006714373,0.00001662714,0.00001036888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005875664,0.0004836828,0.01664059,0.001092742,0.0006283878,0.0009202697,0.0001132615,0.8991603,0.05517257,0.002709305,0.002841897,0.01964944],"study_design_scores_gemma":[0.00003122299,0.0001491979,0.004593243,0.00001322377,0.0001028008,0.00009300105,0.00006493845,0.9885969,0.00368248,0.001106829,0.00154515,0.00002108162],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644703,0.002692044,0.02148469,0.0004117001,0.00006909593,0.00005298405,0.003603049,0.001211619,0.006004556],"genre_scores_gemma":[0.9776158,0.001445444,0.01402942,0.00009005374,0.00002006271,0.00008518754,0.004778014,0.0001049785,0.001831138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01303051,"threshold_uncertainty_score":0.0259093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02457178421155749,"score_gpt":0.3695216025816503,"score_spread":0.3449498183700928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}