{"id":"W4417477140","doi":"10.1002/psc.70068","title":"On‐Resin Pictet–Spengler Cyclization for 1,2,3,4‐Tetrahydro‐β‐carboline‐3‐carboxylate (Tcc) Peptide Synthesis With Acid‐Labile Functional Tolerance","year":2025,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"Synthesis and bioactivity of alkaloids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Université de Montréal; Canadian Institutes of Health Research; Biodiversa+; Centre in Green Chemistry and Catalysis","keywords":"Linker; Peptide; Tryptophan; Peptide synthesis; Cyclic peptide; Side chain","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024271,0.000556294,0.0002480408,0.0002424324,0.0001852623,0.0001562499,0.0003113496,0.0004032626,0.003550997],"category_scores_gemma":[0.000280355,0.0001672368,0.0003194721,0.000248523,0.0002197287,0.0003002223,0.0002630557,0.0006953047,0.001140084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002821672,"about_ca_system_score_gemma":0.000344821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004733735,"about_ca_topic_score_gemma":0.001104373,"domain_scores_codex":[0.9998099,0.00003506019,0.0000126732,0.00004483946,0.00004766367,0.00004985477],"domain_scores_gemma":[0.9998454,0.00002601197,0.00004568946,0.00002921756,0.00001951275,0.00003421512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006726765,0.00004144564,0.0000397915,0.0001354594,0.00001019233,0.0001358433,0.00004046413,0.0002433311,0.9946685,0.0003120979,0.0002235559,0.004082095],"study_design_scores_gemma":[0.00001983623,0.0004658758,0.0008626343,0.000009012871,0.00001420791,0.0004157388,0.00001058128,0.0006391464,0.9898371,0.00006280725,0.007644065,0.00001904618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9040967,0.002899629,0.06689802,0.0002990864,0.0001891908,0.0006571407,0.001297358,0.001059504,0.02260341],"genre_scores_gemma":[0.9543009,0.001783914,0.0321332,0.0001930776,0.00003796511,0.0001878579,0.001063647,0.0001556257,0.01014362],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.003550997,"threshold_uncertainty_score":0.01187932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008296024444415172,"score_gpt":0.2448940533899037,"score_spread":0.2365980289454885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}