{"id":"W4417479592","doi":"10.1016/j.jval.2025.09.686","title":"EE302 Cost-Utility Analysis of Iptacopan for Adult Patients With Paroxysmal Nocturnal Hemoglobinuria Previously Treated With C5 Inhibitor in the Brazilian Private Healthcare System","year":2025,"lang":"en","type":"article","venue":"Value in Health","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"EVERSANA (Canada)","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Hemoglobinuria; Anemia; Healthcare system; Hematologic disease; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001054371,0.0002840662,0.00094103,0.0005161357,0.000193102,0.00001737532,0.0003891706,0.0001337088,0.00001835323],"category_scores_gemma":[0.000119984,0.0001823649,0.0001311267,0.001593443,0.0001325049,0.00006717585,0.00004791694,0.0002616609,0.000002316184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005410176,"about_ca_system_score_gemma":0.0006123307,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01191886,"about_ca_topic_score_gemma":0.008504244,"domain_scores_codex":[0.9958177,0.001681105,0.001188962,0.0005296908,0.0001347114,0.000647845],"domain_scores_gemma":[0.9979367,0.0004426917,0.0005816122,0.000649823,0.000334413,0.00005471951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002299022,0.0004829768,0.9909167,0.002402426,0.0004945984,0.000002193309,0.0009253449,0.0005443053,0.00001637408,0.0007615617,0.0003262038,0.0008282532],"study_design_scores_gemma":[0.006394343,0.001194637,0.9867632,0.002143222,0.0003411741,0.000003271612,0.001534418,0.0007325458,0.0002015033,0.00002006384,0.0004809412,0.000190654],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918625,0.001046969,0.0001100095,0.0007715709,0.0001676473,0.005212891,0.0007478141,0.00004378521,0.00003680476],"genre_scores_gemma":[0.998436,0.00001348895,0.00009009601,0.0003392528,0.00001162617,0.0004834675,0.0005833652,0.0000152106,0.00002745884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006573526,"threshold_uncertainty_score":0.9946609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546700397397972,"score_gpt":0.2761667471047314,"score_spread":0.2606997431307517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}