{"id":"W4417479775","doi":"10.1016/j.jval.2025.09.687","title":"EE303 Cost-Utility Analysis of Iptacopan vs. C5 Inhibitors in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria Naïve to Complement Inhibitors in the Brazilian Private Healthcare System","year":2025,"lang":"en","type":"article","venue":"Value in Health","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"EVERSANA (Canada)","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Hemoglobinuria; Eculizumab; Complement (music); Healthcare system; Complement system; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002080479,0.0003725141,0.001176108,0.001350235,0.000187712,0.00002363283,0.0005979048,0.0001577991,0.00004715004],"category_scores_gemma":[0.0001583223,0.0002884969,0.0001608985,0.003208791,0.0001274637,0.00008197121,0.0002005179,0.0005079928,0.00001132703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001392711,"about_ca_system_score_gemma":0.0005856415,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.03846505,"about_ca_topic_score_gemma":0.03149421,"domain_scores_codex":[0.9928695,0.003007281,0.00222415,0.0007210847,0.0002721596,0.0009058182],"domain_scores_gemma":[0.9978728,0.0004207634,0.0006062115,0.0007961545,0.0002048068,0.00009930527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008684258,0.0006180915,0.9889843,0.001234847,0.0002110022,0.000005535787,0.002828832,0.001984508,0.00002831669,0.001052099,0.00101967,0.001164346],"study_design_scores_gemma":[0.003643083,0.0005289105,0.9875249,0.002304299,0.00008445841,0.000001568443,0.003659179,0.0003585351,0.000221582,0.00002537544,0.001422248,0.0002258731],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904615,0.0006654243,0.00002484975,0.003000624,0.0006866953,0.004434973,0.0006238135,0.00003679813,0.00006530341],"genre_scores_gemma":[0.9982585,0.00001245427,0.00006341466,0.0009220266,0.00001934051,0.0003108047,0.0003876383,0.00001626176,0.000009576709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007796965,"threshold_uncertainty_score":0.9999567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01584302565479924,"score_gpt":0.2848360759610005,"score_spread":0.2689930503062013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}