{"id":"W4417480112","doi":"10.1016/j.jval.2025.09.230","title":"CO128 Health Technology Assessment, Reimbursement, and Funding Landscape Challenges for Oncology Companion Diagnostics in Europe and Canada","year":2025,"lang":"en","type":"article","venue":"Value in Health","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Precision oncology; Biomarker; Selection (genetic algorithm); Precision medicine; Biomarker discovery; Health technology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01817466,0.0005066376,0.0007520986,0.004116641,0.004578734,0.01693181,0.00252887,0.005335327,0.01072152],"category_scores_gemma":[0.04419919,0.0004800361,0.001277526,0.003812454,0.002766742,0.00246341,0.002912028,0.004130428,0.0007936735],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.1334691,"about_ca_system_score_gemma":0.4373274,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9631441,"about_ca_topic_score_gemma":0.9735275,"domain_scores_codex":[0.9791512,0.002691242,0.0007519607,0.000942782,0.0115341,0.004928729],"domain_scores_gemma":[0.918644,0.009958817,0.00246315,0.0007577601,0.05061934,0.01755697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007742463,0.000394872,0.07767594,0.0009033561,0.0004145748,0.0008875089,0.00129184,0.00659578,0.001929048,0.1831146,0.4414873,0.2845309],"study_design_scores_gemma":[0.0002268799,0.0002573219,0.115674,0.003056093,0.0003146324,0.0005899466,0.004937513,0.01196114,0.002059694,0.02105122,0.8395647,0.00030684],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.07126532,0.03235813,0.003681986,0.7361337,0.003331912,0.0004703329,0.006673252,0.0002854573,0.1457999],"genre_scores_gemma":[0.7449508,0.03680407,0.02491619,0.1030574,0.00220487,0.0002966111,0.007060595,0.0004025621,0.08030707],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.8665309,"threshold_uncertainty_score":0.9683908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0730116779306706,"score_gpt":0.3845801909537309,"score_spread":0.3115685130230603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}