{"id":"W4417481054","doi":"10.1016/j.jval.2025.09.160","title":"CO58 Comparative Efficacy of Iptacopan Monotherapy vs. Danicopan Add-on to C5i in Paroxysmal Nocturnal Hemoglobinuria (PNH) Results From an Indirect Treatment Comparison (ITC)","year":2025,"lang":"en","type":"article","venue":"Value in Health","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"EVERSANA (Canada)","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Clinical trial; Anemia; Hemoglobinuria; Complement (music)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002024576,0.001443036,0.004062496,0.0005122164,0.0003286121,0.001269938,0.0009661038,0.001686069,0.008003744],"category_scores_gemma":[0.002964084,0.0005491318,0.004691037,0.00053336,0.0009229383,0.001115576,0.000516539,0.002805872,0.0009833744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00121507,"about_ca_system_score_gemma":0.0008687666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002522781,"about_ca_topic_score_gemma":0.004094977,"domain_scores_codex":[0.9978307,0.00127535,0.0001611625,0.0003211788,0.0001690601,0.0002426071],"domain_scores_gemma":[0.9976373,0.001229728,0.0003966601,0.0001718533,0.0001834802,0.0003810394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9779215,0.001184221,0.001025873,0.0008087538,0.006587323,0.00003385777,0.00003538069,0.0002174869,0.001159396,0.0001128455,0.000321599,0.01059181],"study_design_scores_gemma":[0.7655123,0.1824847,0.02230243,0.0003589692,0.0238811,0.00009193824,0.0001343333,0.001255137,0.001633653,0.0003908059,0.001885318,0.00006935852],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801621,0.01122738,0.0004865111,0.0004185308,0.0008251048,0.0006904427,0.001792221,0.00004742484,0.004350241],"genre_scores_gemma":[0.9938082,0.001986299,0.0004885545,0.0002850317,0.0002781667,0.0003956089,0.0008948487,0.00001372138,0.001849549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008003744,"threshold_uncertainty_score":0.02677518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08828687517448482,"score_gpt":0.3890035714319796,"score_spread":0.3007166962574948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}