{"id":"W4417481256","doi":"10.1016/j.jval.2025.09.1993","title":"HTA208 Integrating Real-World Evidence for Advanced Therapies in Inflammatory Bowel Disease Into Reimbursement Submissions: Insights and Considerations From the UK","year":2025,"lang":"en","type":"article","venue":"Value in Health","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Thermo Fisher Scientific (Canada)","funders":"","keywords":"Inflammatory bowel disease; Reimbursement; Inflammatory Bowel Diseases; Disease; MEDLINE; Infliximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07949675,0.0005986114,0.001724957,0.003456213,0.002426345,0.02379662,0.002664343,0.01409183,0.06073911],"category_scores_gemma":[0.342799,0.000833855,0.002334124,0.004150152,0.003949744,0.01024955,0.006619298,0.009834916,0.009822043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01111082,"about_ca_system_score_gemma":0.04193911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01801363,"about_ca_topic_score_gemma":0.03283624,"domain_scores_codex":[0.8973236,0.05616191,0.01308175,0.002393624,0.02447661,0.006562605],"domain_scores_gemma":[0.5097537,0.3086622,0.02127287,0.01332092,0.1136619,0.03332839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001439026,0.0001952099,0.009699669,0.002672101,0.0003268558,0.001187072,0.001666501,0.001548106,0.001024253,0.06006521,0.6792387,0.2409373],"study_design_scores_gemma":[0.0007352903,0.0007963277,0.02961836,0.01253576,0.0004032414,0.001182736,0.002438708,0.002857449,0.0009898423,0.03080748,0.9172038,0.0004309262],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.01346038,0.02048277,0.004986408,0.8143808,0.01771405,0.0005285172,0.004772893,0.0005037126,0.1231704],"genre_scores_gemma":[0.4416457,0.03364049,0.03921151,0.3436638,0.04126253,0.001336612,0.006871199,0.001717174,0.09065089],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.07949675,"threshold_uncertainty_score":0.420424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03005220319483021,"score_gpt":0.333570141311032,"score_spread":0.3035179381162018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}