{"id":"W4417485252","doi":"10.1016/j.intimp.2025.116052","title":"“Emerging precision drug delivery systems for controlled activation of the cGAS–STING pathway in Cancer, infection, and autoimmune disorders”","year":2025,"lang":"en","type":"review","venue":"International Immunopharmacology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Discovery Centre","funders":"Rajiv Gandhi University of Health Sciences; Indian Council of Medical Research","keywords":"Stimulator of interferon genes; Sting; Innate immune system; Interferon; Acquired immune system; Cytokine; Immunotherapy; Drug delivery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007467492,0.0003739729,0.001456812,0.0006513239,0.0001953901,0.00002697451,0.0005347717,0.0004016517,0.0001288326],"category_scores_gemma":[0.0005676612,0.0002747328,0.000455472,0.0002549052,0.0001788728,0.0001293609,0.000345269,0.0006022707,0.000006104255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003571884,"about_ca_system_score_gemma":0.0005657224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001578166,"about_ca_topic_score_gemma":0.00007388667,"domain_scores_codex":[0.9969072,0.001028311,0.001292688,0.0003874471,0.00006491488,0.0003194886],"domain_scores_gemma":[0.9957851,0.002704502,0.001014077,0.0002122747,0.0002751464,0.000008867123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002777512,0.0003662488,0.0001226197,0.004999498,0.002947102,8.446107e-7,0.0003507278,0.0001652551,0.02545466,0.0006184546,0.001774321,0.9604228],"study_design_scores_gemma":[0.006058746,0.00008241659,0.0002012677,0.0107886,0.0003649738,0.00001817463,0.00005708693,0.0001590622,0.002005431,0.00003679454,0.9799654,0.0002620186],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009104272,0.9767357,0.00006762206,0.0001705264,0.01096122,0.00254351,0.0001394413,0.00003042705,0.0002473011],"genre_scores_gemma":[0.02512176,0.9667778,0.000004651994,0.00004360727,0.00005730021,0.001574807,0.0001352435,0.00002891496,0.006255907],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9781911,"threshold_uncertainty_score":0.9999705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740224131456456,"score_gpt":0.3386970052615144,"score_spread":0.3212947639469498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}