{"id":"W4417485603","doi":"10.1016/s2213-8587(25)00290-6","title":"Zodasiran, an RNAi therapeutic targeting ANGPTL3, for treating patients with homozygous familial hypercholesterolaemia (GATEWAY): an open-label, randomised, phase 2 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Université de Montréal; Université Laval","funders":"Arrowhead Pharmaceuticals","keywords":"RNA interference; Clinical trial; Phase (matter); MEDLINE; Hydroxymethylglutaryl-CoA Reductase Inhibitors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006711402,0.0003964326,0.00126853,0.0001416968,0.000415007,0.0001277593,0.0007653104,0.0001236994,0.00002940961],"category_scores_gemma":[0.0003188296,0.0002476765,0.00008066679,0.0002572492,0.0002669675,0.0003625272,0.0001463738,0.000373089,0.000005840127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004361723,"about_ca_system_score_gemma":0.0001662196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007245692,"about_ca_topic_score_gemma":0.00003354705,"domain_scores_codex":[0.9967057,0.0004729499,0.0005406209,0.0006367264,0.0002059664,0.001437996],"domain_scores_gemma":[0.9981001,0.0004905523,0.0002078484,0.0008622269,0.0001893024,0.0001499495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5514336,0.008415702,0.08520129,0.0003146799,0.001347199,0.00002391261,0.001768622,0.00002145702,0.02508749,0.001788647,0.001814888,0.3227825],"study_design_scores_gemma":[0.9651803,0.008009125,0.009850042,0.00008307205,0.001071625,0.000005183853,0.0005005759,0.0004913525,0.003062609,0.0009589795,0.01036955,0.0004175977],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910492,0.0009594974,0.0001345723,0.001002457,0.0007676614,0.004799169,0.00009217251,0.0001782239,0.001017095],"genre_scores_gemma":[0.9903954,0.00009634109,0.001276165,0.005457643,0.001060036,0.001018544,0.0004316562,0.0000662697,0.0001979383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4137467,"threshold_uncertainty_score":0.9999976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0406784810614475,"score_gpt":0.3483097237388609,"score_spread":0.3076312426774134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}