{"id":"W4417490866","doi":"10.1093/infdis/jiaf636","title":"Higher Promoter Methylation of the Ubiquitin-Associated and SH3 Domain Containing A ( <i>UBASH3A</i> ) Gene Is Associated With T-Lymphocyte Ontogeny and Reduced Susceptibility to Early-Onset Sepsis","year":2025,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; St. Paul's Hospital; BC Cancer Agency; Simon Fraser University; Prevention of Organ Failure; Dalhousie University; BC Children's Hospital; University of British Columbia; SNC-Lavalin (Canada)","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Killam Trusts; GlaxoSmithKline","keywords":"Epigenetics; DNA methylation; Methylation; Gene; Genotype; Promoter; Gene expression; Regulation of gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891503,0.0002062155,0.0001822176,0.0003472561,0.0001320325,0.0002297491,0.0001486596,0.0002079947,0.001646714],"category_scores_gemma":[0.0005150472,0.0001225568,0.0002082706,0.0002534261,0.000163557,0.00006849207,0.0001976705,0.0002473284,0.0001493614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001154008,"about_ca_system_score_gemma":0.0001530353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00177454,"about_ca_topic_score_gemma":0.001563942,"domain_scores_codex":[0.999887,0.00003079984,0.000006576152,0.00003979627,0.00001828668,0.00001764259],"domain_scores_gemma":[0.9997261,0.00007044464,0.0001029362,0.00002502912,0.00002065829,0.00005483649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002034996,0.00006934817,0.6072805,0.00005400562,0.0001657397,0.0004510268,0.0002680311,0.0002545693,0.3803442,0.000126053,0.0001188072,0.008832887],"study_design_scores_gemma":[0.000005863984,0.0001549986,0.9874463,0.000003806307,0.00003215563,0.0004770269,0.00004517789,0.0003470663,0.01121659,0.00005467547,0.0002121697,0.000004194823],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989614,0.0001106203,0.0004787831,0.00001130669,0.000002369578,0.000002988357,0.0002630961,0.000007971415,0.0001613721],"genre_scores_gemma":[0.9989725,0.00006930278,0.0003557297,0.00000957737,0.00000252756,0.000005404906,0.0001619874,0.00000552053,0.0004175129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00177454,"threshold_uncertainty_score":0.00550884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007448918149788274,"score_gpt":0.2493329156906079,"score_spread":0.2418839975408197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}