{"id":"W4417497017","doi":"10.64898/2025.12.16.694699","title":"Gestational inhibition of CSF1R signaling using PLX5622 drives musculoskeletal changes in postnatal offspring","year":2025,"lang":"","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Craniofacial; Offspring; Mastication; Fetus; Tongue; Embryogenesis; Osteoclast; Bone development","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001797135,0.0003459426,0.0003869186,0.0002714394,0.0001886407,0.0003480109,0.0002567784,0.0003929926,0.002022015],"category_scores_gemma":[0.0001409265,0.0001851618,0.0002771761,0.0001144829,0.0004449418,0.0001804821,0.0003096254,0.001176492,0.0003334472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002690212,"about_ca_system_score_gemma":0.0003951273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001269992,"about_ca_topic_score_gemma":0.002291061,"domain_scores_codex":[0.9997551,0.0000238864,0.0000283272,0.00006492674,0.00007870024,0.00004909732],"domain_scores_gemma":[0.9998068,0.0000274387,0.00007556003,0.00001728415,0.00001387662,0.00005906335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001437023,0.00003448433,0.0004334097,0.00003097367,0.000005081076,0.0001307162,0.00002898905,0.00005686849,0.9970554,0.00008369162,0.00005500604,0.001941707],"study_design_scores_gemma":[0.00001816338,0.0005117235,0.008974601,0.00001529889,0.0000182969,0.0002979049,0.0001173126,0.0004898813,0.9874774,0.00004702522,0.002025614,0.000006822819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929026,0.001295256,0.002938998,0.0002622619,0.00004922184,0.00003343437,0.001052839,0.000112966,0.001352467],"genre_scores_gemma":[0.9881493,0.001299027,0.002875361,0.0001700055,0.00001403585,0.0001234427,0.0004820449,0.00005242888,0.006834338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022015,"threshold_uncertainty_score":0.006764352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380399324867292,"score_gpt":0.2540508211061957,"score_spread":0.2402468278575228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}