{"id":"W4417497881","doi":"10.1016/j.cell.2025.11.023","title":"Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses","year":2025,"lang":"en","type":"article","venue":"Cell","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Charles A. King Trust; Magyar Tudományos Akadémia; Damon Runyon Cancer Research Foundation; American Association of Immunologists; Howard Hughes Medical Institute","keywords":"Germinal center; Messenger RNA; Cell; B cell; Adjuvant; RNA; Antibody; Cell type","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574292,0.0004322273,0.0002687433,0.0002244679,0.0001183249,0.0004098032,0.0001271459,0.0003484243,0.0007601764],"category_scores_gemma":[0.0002196059,0.0001462253,0.0002172911,0.0001100465,0.0002668623,0.0002939325,0.0002504319,0.0005504636,0.0004202802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003175663,"about_ca_system_score_gemma":0.0002723846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001297111,"about_ca_topic_score_gemma":0.0003225899,"domain_scores_codex":[0.9997955,0.0000328617,0.00001276766,0.0000405,0.00006490906,0.00005350207],"domain_scores_gemma":[0.9998894,0.00002348398,0.00003166368,0.00001423586,0.0000155843,0.00002553081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003366439,0.00001274461,0.00009792455,0.00002315176,0.000002028059,0.00001726728,0.000006291331,0.00008036769,0.9975345,0.0001582166,0.0000146884,0.002019193],"study_design_scores_gemma":[0.000008134255,0.0002753485,0.0009116417,0.000003873501,0.00001178893,0.000075861,0.00001525115,0.0006169885,0.9962788,0.00009295162,0.001706717,0.000002672847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812946,0.001776694,0.01275051,0.0001599627,0.00008353353,0.00008769079,0.0001454728,0.000175892,0.003525696],"genre_scores_gemma":[0.988834,0.0007196646,0.008184491,0.0001108843,0.00003348336,0.00004371817,0.0001730534,0.00005371132,0.001847007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007601764,"threshold_uncertainty_score":0.002543032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116359095994604,"score_gpt":0.2512328190473995,"score_spread":0.2400692280874534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}