{"id":"W4417497881","doi":"10.1016/j.cell.2025.11.023","title":"Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses","year":2025,"lang":"en","type":"article","venue":"Cell","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Charles A. King Trust; Magyar Tudományos Akadémia; Damon Runyon Cancer Research Foundation; American Association of Immunologists; Howard Hughes Medical Institute","keywords":"Germinal center; Messenger RNA; Cell; B cell; Adjuvant; RNA; Antibody; Cell type","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001964057,0.000180671,0.0003146671,0.0002333409,0.0001624144,0.00001268619,0.0002988045,0.0001170391,0.0003516492],"category_scores_gemma":[0.00006854816,0.0001509026,0.00009713463,0.0002526497,0.0001166765,0.00002544649,0.000132369,0.0001542074,0.0004202703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000295552,"about_ca_system_score_gemma":0.00007454467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000523843,"about_ca_topic_score_gemma":0.000002554406,"domain_scores_codex":[0.9987678,0.0003062648,0.0003698347,0.0002321675,0.00002994759,0.0002939814],"domain_scores_gemma":[0.9992396,0.0002138397,0.0000869921,0.0003439258,0.0001004174,0.0000152582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005043,0.0003403414,0.002842308,0.00004337266,0.0000836766,0.000004430827,0.0002616628,0.00001152617,0.9858885,0.00006507381,0.002586375,0.002829693],"study_design_scores_gemma":[0.002156627,0.0001590611,0.07337518,0.0001055379,0.00002297812,0.00001567691,0.00009249263,0.000006095043,0.7934268,0.000006008153,0.1304845,0.0001491141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918686,0.003374415,0.00008721077,0.0001676309,0.001134044,0.0002467516,0.00005932743,0.0000354628,0.003026518],"genre_scores_gemma":[0.9777833,0.00004859566,0.00004613139,0.0003241826,0.000008315534,0.00001237101,0.00004586663,0.00001182882,0.02171936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1924618,"threshold_uncertainty_score":0.6153629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116359095994604,"score_gpt":0.2512328190473995,"score_spread":0.2400692280874534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}