{"id":"W4417502401","doi":"10.64898/2025.12.18.695245","title":"Mechanoresilience of lysosomes conferred by TMEM63A","year":2025,"lang":"","type":"article","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Hydrostatic pressure; Limiting; Membrane; Lysis; Tension (geology); Lysosome; Cell; Osmotic pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001650625,0.0002313149,0.0001725179,0.0001591835,0.0001760131,0.0003370691,0.000176385,0.000340635,0.00127322],"category_scores_gemma":[0.0001809699,0.0001356999,0.0002139498,0.00006723225,0.0003500244,0.000170404,0.0003871632,0.0004323997,0.0003308623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002037632,"about_ca_system_score_gemma":0.0001177884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000397021,"about_ca_topic_score_gemma":0.0003590721,"domain_scores_codex":[0.9998491,0.00002334682,0.00002200133,0.0000232638,0.00004706881,0.00003511909],"domain_scores_gemma":[0.9998174,0.00002988513,0.00005362216,0.00002854102,0.00001479586,0.00005578296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004956401,0.000007736002,0.0001038617,0.000006082913,0.000001357269,0.00006624805,0.000005314413,0.00001768001,0.9994338,0.00008516751,0.000009974297,0.0002132904],"study_design_scores_gemma":[0.00001685558,0.0001164334,0.004860966,0.000004101559,0.000004104463,0.0006645525,0.0000240372,0.0006858232,0.9925559,0.00008880589,0.0009723745,0.00000599707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975144,0.0003132569,0.001281348,0.00007978317,0.00003223596,0.000007790917,0.0001253562,0.00006014446,0.0005856882],"genre_scores_gemma":[0.9988918,0.00007363735,0.000395652,0.00002004294,0.000004675894,0.000006165385,0.0000760353,0.000009679266,0.000522371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00127322,"threshold_uncertainty_score":0.004259348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005302929276858269,"score_gpt":0.2137334606594554,"score_spread":0.2084305313825971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}