{"id":"W4417502708","doi":"10.1158/1055-9965.epi-25-1006","title":"Germline Predisposition to Oncogenic Alkylating Damage in Colorectal Cancer","year":2025,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Nutritional Studies and Diet","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institutes of Health; Cancer Research UK; National Cancer Institute; Janssen Pharmaceuticals; Centers for Disease Control and Prevention; American Cancer Society","keywords":"Colorectal cancer; Germline; Cancer; Germline mutation; Genetic predisposition; Colonic disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002198699,0.0002476502,0.0001957081,0.0006598684,0.000277531,0.0002981235,0.0001794515,0.0003286472,0.004021214],"category_scores_gemma":[0.0008026077,0.0001010864,0.0002983197,0.0009474945,0.0001859757,0.0001073603,0.0002535508,0.0002038619,0.000296284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629288,"about_ca_system_score_gemma":0.0001622816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002206369,"about_ca_topic_score_gemma":0.003568731,"domain_scores_codex":[0.9997373,0.00003349556,0.00002260409,0.0001169162,0.00005281142,0.00003683141],"domain_scores_gemma":[0.9995742,0.0000651692,0.0002169878,0.00003882652,0.00002912666,0.00007565867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005355561,0.00003979625,0.967424,0.0001192082,0.0003873415,0.0009259507,0.0001212081,0.0003508533,0.02033063,0.0002947651,0.0004414082,0.009029381],"study_design_scores_gemma":[0.00001197828,0.0001241263,0.9941625,0.00001968131,0.0001643492,0.001929652,0.00005333367,0.0003556055,0.001281105,0.0002618699,0.00162788,0.000007881225],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964368,0.0008783615,0.00044137,0.00007037374,0.00001415986,0.000009646578,0.001056883,0.00002715215,0.001065299],"genre_scores_gemma":[0.9989738,0.0001511905,0.0002622834,0.00002348533,0.000008563817,0.000003623469,0.0003715799,0.000004837264,0.0002005003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004021214,"threshold_uncertainty_score":0.01345235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03905711793665221,"score_gpt":0.4148020960733982,"score_spread":0.375744978136746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}