{"id":"W4417502959","doi":"10.3390/vaccines14010003","title":"Randomized Phase 3 Trial Evaluating the Safety, Tolerability, and Immunogenicity of V114, a 15-Valent PCV, Followed by PPSV23 6 Months Later (PNEU-DAY): Subgroup Analysis in Adults 18–49 Years of Age Enrolled at Center for Indigenous Health Sites","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"Respiratory viral infections research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"Johns Hopkins University","keywords":"Immunogenicity; Subgroup analysis; Serotype; Pooled analysis; Randomized controlled trial; Antibody response; Interim analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005263595,0.0002151715,0.001725346,0.0006237352,0.0001546115,0.00002313801,0.0001741382,0.0001133433,0.00009455007],"category_scores_gemma":[0.001955794,0.0001493604,0.0006228884,0.001116971,0.0001009245,0.00007070084,0.0001717525,0.0001967651,0.000001144265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002096373,"about_ca_system_score_gemma":0.0002039412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0015412,"about_ca_topic_score_gemma":0.00215398,"domain_scores_codex":[0.9959864,0.001283436,0.001546549,0.0004160463,0.0003979121,0.0003696411],"domain_scores_gemma":[0.9971566,0.001524075,0.0004285496,0.0005472212,0.000262679,0.00008085444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.884396,0.001676726,0.08727085,0.0005283779,0.001648714,0.000003677288,0.002216164,0.00005858587,0.01752515,0.000002530782,0.0003548012,0.004318387],"study_design_scores_gemma":[0.9377618,0.003903165,0.04729544,0.0002186632,0.0008716995,0.000001648764,0.0001494469,0.003635957,0.005840307,0.00006330625,0.0001070135,0.0001515329],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895614,0.002485322,0.00007178877,0.000323458,0.00009564403,0.007228816,0.000154187,0.00001850513,0.00006083578],"genre_scores_gemma":[0.9985597,0.0003433901,0.0000690965,0.0001055719,0.0000367084,0.0004184867,0.0001268116,0.00001815019,0.0003220956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05336578,"threshold_uncertainty_score":0.6090742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04322266025556792,"score_gpt":0.4144030936951496,"score_spread":0.3711804334395817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}