{"id":"W4417502959","doi":"10.3390/vaccines14010003","title":"Randomized Phase 3 Trial Evaluating the Safety, Tolerability, and Immunogenicity of V114, a 15-Valent PCV, Followed by PPSV23 6 Months Later (PNEU-DAY): Subgroup Analysis in Adults 18–49 Years of Age Enrolled at Center for Indigenous Health Sites","year":2025,"lang":"en","type":"article","venue":"Vaccines","topic":"Respiratory viral infections research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"Johns Hopkins University","keywords":"Immunogenicity; Subgroup analysis; Serotype; Pooled analysis; Randomized controlled trial; Antibody response; Interim analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002205345,0.001571631,0.003232065,0.0002818136,0.0004636432,0.001252322,0.0008904707,0.001515826,0.005483746],"category_scores_gemma":[0.003104113,0.0005863805,0.003225695,0.0004150847,0.0007495918,0.001060318,0.0004624702,0.003246619,0.0006773759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001159607,"about_ca_system_score_gemma":0.001738275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001557437,"about_ca_topic_score_gemma":0.003752402,"domain_scores_codex":[0.9990187,0.0005467457,0.00006019232,0.0001796163,0.00005980717,0.0001350427],"domain_scores_gemma":[0.9983841,0.0004698746,0.0004548848,0.0001569897,0.0001470173,0.0003871853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9880261,0.002650302,0.001014289,0.0003824721,0.00194031,0.00002867991,0.00004117346,0.0001847693,0.0008305564,0.00004586595,0.0004636084,0.004391913],"study_design_scores_gemma":[0.9198983,0.0730691,0.003785028,0.00005052436,0.001631332,0.00004035748,0.00004964163,0.0004430942,0.0002733114,0.0002045755,0.000535603,0.00001915313],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858465,0.004247215,0.0005784837,0.0004945064,0.0004497186,0.005116655,0.001736463,0.00009507284,0.001435439],"genre_scores_gemma":[0.9862179,0.001501945,0.001321261,0.0009158853,0.0002635845,0.006233777,0.001562657,0.00002880581,0.00195421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005483746,"threshold_uncertainty_score":0.01834494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04322266025556792,"score_gpt":0.4144030936951496,"score_spread":0.3711804334395817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}