{"id":"W4417503772","doi":"10.1093/braincomms/fcaf468","title":"Stable isotope labelling kinetics of neurofilament light","year":2025,"lang":"en","type":"article","venue":"Brain Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"Horizon 2020; Olav Thon Stiftelsen; UK Dementia Research Institute; Cure Alzheimer's Fund; Vetenskapsrådet; Medical Research Council Canada; Hjärnfonden; University College London; HORIZON EUROPE Framework Programme; European Partnership on Metrology; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; National Institute on Aging; Alzheimer's Association; HORIZON EUROPE European Research Council; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; Alzheimer's Drug Discovery Foundation","keywords":"Labelling; Kinetics; Tauopathy; Human brain; Extracellular; Neurofilament","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824037,0.00007045229,0.0001722728,0.0001149668,0.00008925665,0.00001436044,0.0005090539,0.00004921588,0.0001207088],"category_scores_gemma":[0.0002731092,0.00006307266,0.00005054239,0.0004659409,0.0001211249,0.00003202603,0.0004731913,0.0002295825,0.000023779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006291655,"about_ca_system_score_gemma":0.00008131165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009003041,"about_ca_topic_score_gemma":0.00002573387,"domain_scores_codex":[0.9991488,0.0001190505,0.0002782746,0.0001160946,0.0001742837,0.0001634398],"domain_scores_gemma":[0.9976568,0.0003420582,0.00005248776,0.001704621,0.0001856812,0.00005832249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005372916,0.0009053739,0.005181351,0.0001592374,0.0001175867,0.000001914571,0.000417747,0.00004793398,0.9221881,0.03382912,0.02896108,0.008136819],"study_design_scores_gemma":[0.001785973,0.000337905,0.09950826,0.0006873722,0.00009751242,0.000005099619,0.0001759464,0.005173796,0.07746167,0.001277793,0.8133077,0.0001809735],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2979032,0.004041968,0.003800372,0.488251,0.0001494975,0.001865512,0.00002742236,0.0001787953,0.2037822],"genre_scores_gemma":[0.9791518,0.0009398707,0.008086187,0.001444501,0.00001312635,0.00004287163,0.00002876515,0.00001182282,0.01028101],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8447264,"threshold_uncertainty_score":0.2572028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05392593314333013,"score_gpt":0.3576667586559352,"score_spread":0.3037408255126051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}