{"id":"W4417506867","doi":"10.1158/1078-0432.ccr-25-3541","title":"Investigating Early Kinetics in Plasma ctDNA and Peripheral T-cell Receptor Repertoire to Predict Treatment Outcomes to PD-1 Inhibitors in Head and Neck Squamous Cell Carcinoma","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"Eisai; Genentech; AstraZeneca; Canada Research Chairs; Genomic Health; Natera; Menarini Silicon Biosystems","keywords":"Repertoire; Head and neck; Head and neck squamous-cell carcinoma; T-cell receptor; Peripheral; Head and neck cancer; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008931601,0.0003412044,0.0005349714,0.0003599901,0.0002510759,0.0006041192,0.0002938005,0.0003816164,0.0009493121],"category_scores_gemma":[0.001199204,0.0002242696,0.0002678054,0.000312009,0.0002852635,0.0003549392,0.000290613,0.0004952875,0.0002770276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004668732,"about_ca_system_score_gemma":0.000350421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006387862,"about_ca_topic_score_gemma":0.0009131895,"domain_scores_codex":[0.9996432,0.00009501835,0.00002646702,0.0001156172,0.00007376124,0.00004592176],"domain_scores_gemma":[0.9993888,0.000144793,0.0002040573,0.00005870006,0.00008459881,0.0001190313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0122389,0.0007927559,0.8915321,0.0001611535,0.0002648921,0.0001590094,0.0001967253,0.001685282,0.04942476,0.00004215606,0.0004260064,0.04307627],"study_design_scores_gemma":[0.0003302149,0.006388708,0.9755888,0.00002224034,0.0002118657,0.0005672598,0.0001307318,0.00443497,0.01114865,0.00009575378,0.00106366,0.00001719448],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988477,0.000374957,0.0002404684,0.00001511359,0.000004680198,0.00003941162,0.0001723262,0.00001132668,0.000294017],"genre_scores_gemma":[0.9990182,0.00008148274,0.0002705732,0.00004493498,0.000007337994,0.00004748022,0.0003712098,0.000004423433,0.0001543541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009493121,"threshold_uncertainty_score":0.004723549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0896926933238834,"score_gpt":0.4311432024017427,"score_spread":0.3414505090778593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}