{"id":"W4417515871","doi":"10.1016/j.ocarto.2025.100737","title":"A randomized, double-blind, placebo-controlled and dose-ranging study to evaluate the safety and efficacy of XG005 in subjects with painful osteoarthritis of the knee","year":2025,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage Open","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Research and Development","keywords":"Osteoarthritis; Clinical trial; Quality of life (healthcare); MEDLINE; Arthropathy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002221322,0.001238481,0.002216439,0.000489647,0.0005330317,0.0006404454,0.0009131086,0.002034003,0.006734801],"category_scores_gemma":[0.001874223,0.0005451324,0.0008372903,0.0003698661,0.001327194,0.000816607,0.0003250622,0.001574603,0.000842723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004536404,"about_ca_system_score_gemma":0.001140785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005171738,"about_ca_topic_score_gemma":0.001209267,"domain_scores_codex":[0.9991446,0.0004660119,0.00007156815,0.0001403904,0.00009039698,0.00008707016],"domain_scores_gemma":[0.9989243,0.0003616422,0.0002670739,0.00007648287,0.00009407608,0.0002763178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9622708,0.01826503,0.00077122,0.0005806368,0.0004640874,0.00003651103,0.00005824039,0.0001756371,0.004808316,0.0001029679,0.0004076607,0.01205879],"study_design_scores_gemma":[0.9130879,0.08493906,0.00115371,0.00001507734,0.0001313369,0.00001214249,0.000009503238,0.0001335201,0.0002431513,0.00003598877,0.0002319942,0.000006576814],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841302,0.002543725,0.001187482,0.0003843173,0.0003876961,0.009109886,0.0005828573,0.0001392647,0.001534494],"genre_scores_gemma":[0.9807267,0.001477429,0.00307529,0.001311743,0.0004478224,0.009654231,0.000705772,0.00001477956,0.002586307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006734801,"threshold_uncertainty_score":0.02253014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422582957962353,"score_gpt":0.2810205559424268,"score_spread":0.2667947263628032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}