{"id":"W4417516068","doi":"10.1016/j.mcpro.2025.101496","title":"Comparative Evaluation of Solid-phase and Membrane Mimetic Strategies in Membrane Proteome Coverage and Disease-State Analysis","year":2025,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Regina; University of British Columbia","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Foundation for Innovation; University of British Columbia; Heart and Stroke Foundation of Canada","keywords":"Proteome; Membrane protein; Transmembrane protein; Membrane; Integral membrane protein; Context (archaeology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004692725,0.0002660921,0.0005362806,0.0002921593,0.00008338156,0.00005986234,0.0001692093,0.0001074146,0.00003710492],"category_scores_gemma":[0.00006411356,0.00028754,0.000104097,0.0006473571,0.0001920334,0.0001331509,0.0001180445,0.0002306598,5.349081e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008582741,"about_ca_system_score_gemma":0.0002348919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006456699,"about_ca_topic_score_gemma":0.00001862898,"domain_scores_codex":[0.9983159,0.000105321,0.000514546,0.0005292648,0.0002979404,0.0002369711],"domain_scores_gemma":[0.9989148,0.00003937909,0.000243195,0.0004943424,0.0001882802,0.0001200541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001417724,0.0001876974,0.0001977067,0.0003449011,0.0002366719,0.00001136248,0.0002152571,0.01364663,0.9827977,0.001696307,9.786766e-7,0.0005229833],"study_design_scores_gemma":[0.001405032,0.00002353596,0.00009171688,0.00008225442,0.0006342304,8.821377e-7,0.0001013786,0.1020164,0.866751,0.02865048,0.00002497237,0.0002181091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7781043,0.0007562797,0.2191087,0.0001043201,0.000004275691,0.001372711,0.0001333889,0.00003444481,0.0003816439],"genre_scores_gemma":[0.9834333,0.0001518113,0.01525305,0.00002872659,0.000004922328,0.0008689545,0.0001584784,0.00001972694,0.00008103693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.205329,"threshold_uncertainty_score":0.9999577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566034394873992,"score_gpt":0.3376926914578806,"score_spread":0.3220323475091407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}